| 规格或纯度 | ≥99%(HPLC) |
|---|---|
| 英文名称 | TCS 2314 |
| 别名 | 1-[[((3S)-4-[2-[4-[[[((2-甲基苯基)氨基]羰基]氨基]苯基]乙炔基] l-3-吗啉基]羰基] -4-哌啶二乙酸 |
| 生化机理 | 整联蛋白极晚期抗原4（VLA-4;α4β1）拮抗剂（IC50 = 4.4 nM）。阻止炎症细胞的活化。 |
| 储存温度 | 室温 |
| 运输条件 | 常规运输 |
| IUPAC Name | 2-[1-[(3S)-4-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]morpholine-3-carbonyl]piperidin-4-yl]acetic acid |
|---|---|
| INCHI | InChI=1S/C28H34N4O6/c1-19-4-2-3-5-23(19)30-28(37)29-22-8-6-20(7-9-22)16-25(33)32-14-15-38-18-24(32)27(36)31-12-10-21(11-13-31)17-26(34)35/h2-9,21,24H,10-18H2,1H3,(H,34,35)(H2,29,30,37)/t24-/m0/s1 |
| InChi Key | ITXAAOWFOURIHK-DEOSSOPVSA-N |
| Canonical SMILES | CC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(=O)N3CCOCC3C(=O)N4CCC(CC4)CC(=O)O |
| 分子式 |
C28H34N4O6 |
| PubChem CID | 11226207 |
| 分子量 | 522.59 |
| CAS Registry No. | 317353-73-4 |
|---|---|
| PubChem CID | 11226207 |
| ChEMBL Ligand | CHEMBL389946 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 52.26, 最高浓度(mM): 100；溶于ethanol, 最高浓度 (mg/mL): 26.13, 最高浓度(mM): 50 |
|---|
| Target ID | 2580 |
|---|---|
| 名称 | integrin α4β1 |
| 缩写名 | SHP2 |
| 家族 | Integrins |
| 别名 | Puma-g |
| Ligand ID | 6590 |
|---|---|
| 名称 | TCS2314 |
| 别名 | TCS-2314 |
| 类别 | Synthetic organic |
| 学名 | 2-[1-[(3S)-4-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]morpholine-3-carbonyl]piperidin-4-yl]acetic acid |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. |
￥1,737.90
￥97.90
￥4,950.90
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