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硫黄素T

荧光细胞渗透性淀粉样蛋白结合苯并噻唑盐

CAS编号: 2390-54-7
分子式: C₁₇H₁₉ClN₂S
分子量: 318.86
MDL号: MFCD00011944
PubChem编号: 16953

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货号 (SKU)	包装规格	是否现货	价格	数量
T168914-1g	1g	现货
T168914-5g	5g	现货
T168914-10g	10g	现货
T168914-25g	25g	现货
T168914-100g	100g	期货

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五元杂环化合物苯并噻唑类

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基本描述

别名	硫代黄素T\|碱性黄1\|硫黄素S
英文名称	Thioflavin T
生化机理	荧光细胞渗透性淀粉样蛋白结合苯并噻唑盐。染料用于体内外观察堆积的β片。结合引起最大激发（385 nm至450 nm）和最大发射（445 nm至482 nm）的变化。易溶于水。
储存温度	室温
运输条件	常规运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	硫黄素T是苯并噻唑类染料，与淀粉样蛋白结合后荧光增强。硫黄素T已可用于组织学和蛋白质表征。硫黄素T是苯并噻唑类染料，与淀粉样蛋白结合后荧光增强。硫黄素T已可用于组织学和蛋白质表征。 Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid.Thioflavin T has been used in histology and for protein characterization. Usually used to identify the presence of amyloid fibrils in samples.

名称和标识符

IUPAC Name	4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
INCHI	InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChi Key	JADVWWSKYZXRGX-UHFFFAOYSA-M
Canonical SMILES	CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]
关联CAS	2390-54-7
PubChem CID	16953
分子量	318.86

化学和物理性质

溶解性	solubility in MeOH Clear to Very Slightly Hazy，Yellow to Yellow-Green，1 mg/mL

安全和危险性（GHS）

象形图	Toxic Environmental Hazard Corrosive Harmful
信号词	Danger
危险声明	H319: Causes serious eye irritation H301: Toxic if swallowed H411: Toxic to aquatic life with long lasting effects H318: Causes serious eye damage H317: May cause an allergic skin reaction H400: Very toxic to aquatic life H410: Very toxic to aquatic life with long lasting effects
预防措施声明	P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P316,P305+P354+P338,P317,P337+P317

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参考文献

1. Chu TH et al.. (2017) Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord.. PLoS One, 12 (11): (e0188218). [PMID:29176903]
2. Marathe S et al.. (2017) Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing.. Front Cell Neurosci, 11 (): (220). [PMID:28848392]
3. Brai E et al.. (2016) Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.. Acta Neuropathol Commun, 4 (): (64). [PMID:27364742]
4. Huang DS et al.. (2017) Protective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway.. Evid Based Complement Alternat Med, 2017 (): (3545169). [PMID:28680449]
5. Warner KD et al.. (2017) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein.. Nat Chem Biol, 13 (11): (1195-1201). [PMID:28945234]
6. de Villiers S et al.. (2019) A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study.. Front Neurol, 10 (): (1262). [PMID:31849822]
7. Blancas-Mejia LM et al.. (2019) Assays for Light Chain Amyloidosis Formation and Cytotoxicity.. Methods Mol Biol, 1873 (): (123-153). [PMID:30341607]
8. Sears JC & Broadie K. (2020) FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.. Cell Rep, 33 (2): (108266). [PMID:33053340]
9. Huang C et al.. (2019) Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.. Elife, 8 (): (). [PMID:31050339]
10. Stephens AD et al.. (2019) Isolation and Imaging of His- and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and SIM.. Bio Protoc, 9 (21): (e3408). [PMID:33654909]
11. Peng CC et al.. (2020) Nifedipine Upregulates ATF6-a, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress.. Int J Mol Sci, 21 (9): (). [PMID:32365658]
12. Xu X et al.. (2018) Protein binding protection in combination with DNA masking for sensitive and reliable transcription factor detection.. Talanta, 186 (): (293-298). [PMID:29784364]
13. Zunke F et al.. (2018) Reversible Conformational Conversion of a-Synuclein into Toxic Assemblies by Glucosylceramide.. Neuron, 97 (): (92-107.e10). [PMID:29290548]
14. Monaco A et al.. (2020) The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.. Mol Ther, 28 (4): (1167-1176). [PMID:32087148]
15. Gade Malmos K et al.. (2017) ThT 101: a primer on the use of thioflavin T to investigate amyloid formation.. Amyloid, 24 (): (1-16). [PMID:28393556]

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