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基本描述
| 规格或纯度 | 98% |
|---|---|
| 英文名称 | Terfenadine |
| 别名 | α-[4-(1,1-二甲基乙基)苯基]-4-(羟基二苯基甲基)-1-哌啶丁醇|1-[4-(叔丁基)苯基]-4-[4-(羟基二苯基甲基)哌啶-1-基]丁-1-醇 |
| 英文别名 | terfenadine|50679-08-8|Seldane|Ternadin|Triludan|Teldane|Allerplus|Teldanex|Aldaban|Terdin|Terfenadina|RMI 9918|RMI-9918|1-(4-(tert-butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol|alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylm |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats |
名称和标识符
| IUPAC Name | 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol |
|---|---|
| INCHI | InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3 |
| InChi Key | GUGOEEXESWIERI-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O |
| WGK Germany | 2 |
| PubChem CID | 5405 |
| 分子量 | 471.67 |
数据库链接
| PubChem CID | 5405 |
|---|---|
| ChEBI | CHEBI:9453 |
| CAS Registry No. | 50679-08-8 |
| ChEMBL Ligand | CHEMBL17157 |
| DrugBank Ligand | DB00342 |
| BindingDB Ligand | 50017376 |
| Wikipedia | Terfenadine |
| DrugCentral Ligand | 2600 |
| GPCRdb Ligand | terfenadine |
化学和物理性质
| 溶解性 | Soluble in chloroform, DMSO (100 nM), ethanol (25 nM), and water (0.001 g/100 ml) at 30°C |
|---|---|
| 敏感性 | 对空气、热敏感 |
| 熔点 | 145-152℃ |
安全和危险性（GHS）
| 信号词 | Warning |
|---|---|
| 危险声明 |
H413: May cause long lasting harmful effects to aquatic life H303: May be harmful if swallowed |
| 预防措施声明 | P273,P501,P312 |
| WGK Germany | 2 |
关联配体
| Ligand ID | 2608 |
|---|---|
| 名称 | terfenadine |
| 别名 | Seldane® |
| 类别 | Synthetic organic |
| 学名 | 1-(4-tert-butylphenyl)-4-[4-[hydroxy-di(phenyl)methyl]piperidin-1-yl]butan-1-ol |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Due to adverse effects on cardiac function, terfenadine has largely been superseded by its carboxylic acid metabolite |
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
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