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细胞色素P450
Galeterone,CYP17抑制剂

Galeterone,CYP17抑制剂

CYP17抑制剂;?也是雄激素受体拮抗剂

规格或纯度: ≥98%

CAS编号: 851983-85-2
分子式: C₂₆H₃₂N₂O
分子量: 388.56
PubChem编号: 11188409

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货号 (SKU)	包装规格	是否现货
T127853-5mg	5mg	现货
T127853-25mg	25mg	现货
T127853-100mg	100mg	现货

查看相关系列

Androgen receptor Antagonist CYP17A1 Inhibitor

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基本描述

规格或纯度	≥98%
英文名称	Galeterone
别名	TOK001;TOK 001;TOK-001
英文别名	VN-124-1;VN/124-1;VN 124;3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene
生化机理	CYP17抑制剂（IC50 = 300 nM）和雄激素受体拮抗剂（PC3-AR细胞中IC50 = 384 nM）。在体外抑制DHT刺激的前列腺癌细胞增殖。在携带前列腺癌异种移植物的SCID小鼠中表现出抗肿瘤活性。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	卖完停产，不再备货
产品介绍	TOK-001 (VN/124-1; Galeterone)是多功能抗雄激素和CYP17抑制剂，IC50为47 nM。An antagonist to LNCaP AR TOK-001 (VN/124-1; Galeterone) is a multifunctional antiandrogen and CYP17 inhibitor(IC50=47 nM) in castration resistant prostate cancer (CRPC). An antagonist to LNCaP AR

名称和标识符

IUPAC Name	(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
INCHI	InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChi Key	PAFKTGFSEFKSQG-PAASFTFBSA-N
Canonical SMILES	CC12CCC(CC1=CCC3C2CCC4(C3CC=C4N5C=NC6=CC=CC=C65)C)O
分子式	C₂₆H₃₂N₂O
PubChem CID	11188409
分子量	388.56

数据库链接

PubChem CID	11188409
ChEMBL Ligand	CHEMBL2105738
CAS Registry No.	851983-85-2
Wikipedia	Galeterone
RCSB PDB Ligand	TOK

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): 19.43, 最高浓度(mM): 50；溶于ethanol, 最高浓度 (mg/mL): 19.43, 最高浓度(mM): 50

安全信息

象形图	Health Hazard
信号词	Warning
危险声明	H361: Suspected of damaging fertility or the unborn child H371: May cause damage to organs H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child
预防措施声明	P280,P405,P501,P264,P260,P270,P203,P318,P308+P316

靶标

Target ID

628

名称

Androgen receptor

缩写名

SHP2

家族

3C. 3-Ketosteroid receptors

别名

CKR-L1

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	920	Xq12	AR	androgen receptor
Mouse	2	899	X 42.82 cM	Ar	androgen receptor
Rat	2	902	Xq22	Ar	androgen receptor

Entrez Gene

367 (Hs) , 24208 (Rn) , 11835 (Mm)

OMIM

313700 (Hs)

UniProtKB

P10275 (Hs) , P15207 (Rn) , P19091 (Mm)

RefSeq Nucleotide

NM_000044 (Hs) , NM_012502 (Rn) , NM_013476 (Mm) , NM_001011645 (Hs)

RefSeq Protein

NP_000035 (Hs) , NP_038504 (Mm) , NP_036634 (Rn) , NP_001011645 (Hs)

Ensembl Gene

ENSG00000169083 (Hs) , ENSMUSG00000046532 (Mm) , ENSRNOG00000005639 (Rn)

Orphanet

132285 (Hs)

Protein GI

6978535 (Rn) , 58535455 (Hs) , 7304901 (Mm)

NURSA Receptor

10.1621/D7JZGQS9BU (Hs)

DrugBank Target

P10275 (Hs)

CATH/Gene3D

2.130.10.10 (N/A)

ChEMBL Target

CHEMBL3072 (Rn) , CHEMBL3056 (Mm) , CHEMBL1871 (Hs)

Target ID

1361

名称

CYP17A1

缩写名

SHP2

家族

CYP11, CYP17, CYP19, CYP20 and CYP21 families

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	508	10q24.32	CYP17A1	cytochrome P450 family 17 subfamily A member 1
Mouse	2	507	19 38.97 cM	Cyp17a1	cytochrome P450, family 17, subfamily a, polypeptide 1
Rat	2	507	1q54	Cyp17a1	cytochrome P450, family 17, subfamily a, polypeptide 1

Ensembl Gene

ENSG00000148795 (Hs) , ENSMUSG00000003555 (Mm) , ENSRNOG00000020035 (Rn)

Entrez Gene

13074 (Mm) , 25146 (Rn) , 1586 (Hs)

OMIM

609300 (Hs)

Protein GI

4503195 (Hs) , 160948601 (Mm) , 6978731 (Rn)

UniProtKB

P05093 (Hs) , P27786 (Mm) , P11715 (Rn)

Orphanet

120963 (Hs)

DrugBank Target

P05093 (Hs)

ChEMBL Target

CHEMBL4430 (Rn) , CHEMBL3522 (Hs)

关联配体

Ligand ID	8638
名称	galeterone
别名	TOK-001
类别	Synthetic organic
学名	(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.