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基本描述
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | SIS3 free base |
| 生化机理 | SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 . SIS3 free base does not affect the phosphorylation of Smad2. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 . SIS3 free base does not affect the phosphorylation of Smad2 In Vitro SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Human dermal fibroblasts Concentration: 0.3, 1, 3, 10 μM Incubation Time: For 1 hour Result: Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4. IC50& Target:Smad3, ALK-5 |
名称和标识符
| Canonical SMILES | CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5 |
|---|---|
| 分子量 | 453.53 |
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产品问答
上海阿拉丁生化科技股份有限公司
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