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SNT-207858 free base

规格或纯度: 99%

CAS编号: 1104662-66-9
分子式: C₃₂H₄₃Cl₂N₅O₃
分子量: 616.62
PubChem编号: 42630200

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货号 (SKU)	包装规格	是否现货	价格	数量
S647413-5mg	5mg	期货
S647413-10mg	10mg	期货
S647413-50mg	50mg	期货
S647413-100mg	100mg	期货

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GPCR/G Protein Melanocortin Receptor Neuronal Signaling

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基本描述

规格或纯度	99%
英文名称	SNT-207858 free base
生化机理	SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 ( MC-4 ) receptor antagonist. SNT207858 free base has an IC 50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor In Vitro SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model Dosage: 30 mg/kg Administration: Oral administration; once daily; 15 days Result: Significantly reduced the tumor induced weight loss. Form:Solid IC50& Target:MC-4 receptor

名称和标识符

IUPAC Name	N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[3-[(2R)-2-pyrrolidin-1-ylbutoxy]pyridin-2-yl]piperidin-1-yl]propan-2-yl]pyrrolidine-1-carboxamide
INCHI	InChI=1S/C32H43Cl2N5O3/c1-2-26(37-14-3-4-15-37)22-42-29-8-7-13-35-30(29)23-11-18-38(19-12-23)31(40)28(36-32(41)39-16-5-6-17-39)20-24-9-10-25(33)21-27(24)34/h7-10,13,21,23,26,28H,2-6,11-12,14-20,22H2,1H3,(H,36,41)/t26-,28-/m1/s1
InChi Key	GNSVFEJLUPMLCZ-IXCJQBJRSA-N
Canonical SMILES	CCC(COC1=C(N=CC=C1)C2CCN(CC2)C(=O)C(CC3=C(C=C(C=C3)Cl)Cl)NC(=O)N4CCCC4)N5CCCC5
PubChem CID	42630200
分子量	616.62

化学和物理性质

溶解性	DMSO : 100 mg/mL (162.17 mM; Need ultrasonic)

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