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SMTP-7

有货

库存信息

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库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
S613637-5mg	5mg	期货
S613637-25mg	25mg	期货

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epoxide hydrolase 2 Inhibitor

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基本描述

英文名称	SMTP-7
别名	Stachybotrys microspora triprenyl phenol 7;BIIB131;orniplabin;SMTP7;TMS-007
英文别名	Stachybotrys microspora triprenyl phenol 7;BIIB131;orniplabin;SMTP7;TMS-007

名称和标识符

IUPAC Name	(2S)-2,5-bis[(2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid
INCHI	InChI=1S/C51H68N2O10/c1-30(2)14-9-16-32(5)18-11-21-50(7)43(56)26-36-41(54)24-34-38(45(36)62-50)28-52(47(34)58)23-13-20-40(49(60)61)53-29-39-35(48(53)59)25-42(55)37-27-44(57)51(8,63-46(37)39)22-12-19-33(6)17-10-15-31(3)4/h14-15,18-19,24-25,40,43-44,54-57H,9-13,16-17,20-23,26-29H2,1-8H3,(H,60,61)/b32-18+,33-19+/t40-,43-,44-,50-,51-/m0/s1
InChi Key	CRNDCHORWGDFGR-PXTWCNKMSA-N
Canonical SMILES	CC(=CCC/C(=C/CC[C@]1([C@H](Cc2c(cc3c(c2O1)CN(C3=O)CCC[C@@H](C(=O)O)N1Cc2c3c(c(cc2C1=O)O)C[C@@H]([C@](O3)(C)CC/C=C(\C)/CCC=C(C)C)O)O)O)C)/C)C

关联配体

Ligand ID	12300
名称	SMTP-7
别名	orniplabin
类别	Synthetic organic
学名	(2S)-2,5-bis[(2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	SMTP-7 is a natural triprenyl phenol that's produced by Stachybotrys microspora (a fungus) . It is a complex molecule with 5 chiral centers whose absolute stereochemical configuration has been determined using microcrystal electron diffraction (MicroED) . SMTP-7 produces thrombolytic , anti-inflammatory, and antioxidant effects. It is being considered as a clinical anti-thrombotic agent for use in stroke patients . The compound has activity as a plasminogen modulator and soluble epoxide hydrolase inhibitor that may offer a novel therapeutic intervention for cardiometabolic diseases .

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参考文献

1. Hasumi K, Yamamichi S, Harada T. (2010) Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.. FEBS J, 277 (18): (3675-87). [PMID:20718867]
2. Sawada H, Nishimura N, Suzuki E, Zhuang J, Hasegawa K, Takamatsu H, Honda K, Hasumi K. (2014) SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates.. J Cereb Blood Flow Metab, 34 (2): (235-41). [PMID:24192639]
3. Suzuki E, Nishimura N, Yoshikawa T, Kunikiyo Y, Hasegawa K, Hasumi K. (2018) Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.. Pharmacol Res Perspect, 6 (6): (e00448). [PMID:30546909]
4. Wang B, Lin Y. (2022) Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED).. Chem Commun (Camb), 58 (94): (13071-13074). [PMID:36305866]
5. Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R et al.. (2022) A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol.. Br J Clin Pharmacol, 71 (13): (1755-70). [PMID:36562925]

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