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基本描述
| 英文名称 | SB-747651A |
|---|---|
| 别名 | compound 26 |
| 英文别名 | compound 26 |
名称和标识符
| IUPAC Name | N-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[5,4-d]pyridin-7-yl]methyl]piperidin-4-amine |
|---|---|
| INCHI | InChI=1S/C16H22N8O/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23) |
| InChi Key | MBCJUIJWPYUEBX-UHFFFAOYSA-N |
| Canonical SMILES | CCn1c(nc2c1c(CNC1CCNCC1)cnc2)c1nonc1N |
| PubChem CID | 11393719 |
数据库链接
| ChEMBL Ligand | CHEMBL188434 |
|---|---|
| PubChem CID | 11393719 |
关联配体
| Ligand ID | 8130 |
|---|---|
| 名称 | SB-747651A |
| 别名 | compound 26 |
| 类别 | Synthetic organic |
| 学名 | N-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[5,4-d]pyridin-7-yl]methyl]piperidin-4-amine |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
SB-747651A is a potent inhibitor of ribosomal protein S6 kinase, polypeptide 5 (RPS6KA5), also known as MSK1 |
产品问答
产品问答
参考文献
| 1. Bamford MJ, Bailey N, Davies S, Dean DK, Francis L, Panchal TA, Parr CA, Sehmi S, Steadman JG, Takle AK et al.. (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors.. Bioorg Med Chem Lett, 15 (14): (3407-11). [PMID:15955699] |
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