(3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide
- PubChem编号: 46871820
有货
英文名称 | (3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide |
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别名 | compound 32 |
英文别名 | compound 32 |
IUPAC Name | (3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide |
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INCHI | InChI=1S/C20H17Cl2N3O2/c21-13-3-1-11(2-4-13)15-9-23-10-16(15)20(27)25-18-7-12-5-6-24-19(26)14(12)8-17(18)22/h1-8,15-16,23H,9-10H2,(H,24,26)(H,25,27)/t15-,16+/m0/s1 |
InChi Key | XBFAFSAUQFDEOK-JKSUJKDBSA-N |
Canonical SMILES | O=C([C@@H]1CNC[C@H]1c1ccc(cc1)Cl)Nc1cc2cc[nH]c(=O)c2cc1Cl |
PubChem CID | 46871820 |
ChEMBL Ligand | CHEMBL1082821 |
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PubChem CID | 46871820 |
Ligand ID | 8184 |
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名称 | compound 32 [PMID: 20471253] |
类别 | Synthetic organic |
学名 | (3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide |
生物活性评价 |
Compound 32 inhibition of ROCK2 translates to improved aortic ring potency, compared to a previously identified dual ROCK1/2 inhibitor hit compound , in rat studies |
评价 |
Compound 32 was identified as a Rho kinase 2 (ROCK2) inhibitor |
1. Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER. (2010) Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.. Bioorg Med Chem Lett, 20 (12): (3746-9). [PMID:20471253] |