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Sarilumab (anti-IL-6Rα)

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

种属反应性: Cynomolgus,Human
亚型: Human IgG1

有货

库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
S412003-1mg	1mg	期货
S412003-5mg	5mg	期货
S412003-10mg	10mg	期货

查看相关系列

Interleukin-6 receptor，α subunit Antibody

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基本信息

产品名称	Sarilumab (anti-IL-6Rα)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	IL6R
应用	Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR)
反应种属	Cynomolgus,Human
偶联标记	Unconjugated

产品属性

抗体类型	Primary antibody
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	27.0 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 186.5 kDa, under non-reducing conditions.
纯化方法	Protein A purified
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	1189541-98-7

数据库链接

Wikipedia	Sarilumab
IMGT/mAb-DB	400

靶标

Target ID

1708

名称

Interleukin-6 receptor, α subunit

缩写名

IL6R

家族

IL-6 receptor family

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	468	1q21.3	IL6R	interleukin 6 receptor
Mouse	1	460	3 39.19 cM	Il6ra	interleukin 6 receptor, alpha
Rat	1	462	2q34	Il6r	interleukin 6 receptor

Ensembl Gene

ENSG00000160712 (Hs) , ENSMUSG00000027947 (Mm) , ENSRNOG00000020811 (Rn)

Entrez Gene

16194 (Mm) , 24499 (Rn) , 3570 (Hs)

OMIM

147880 (Hs)

Protein GI

110431356 (Mm) , 164414415 (Rn) , 332309226 (Hs)

UniProtKB

P08887 (Hs) , P22272 (Mm) , P22273 (Rn)

DrugBank Target

P08887 (Hs)

dbSNP

rs4129267 (Hs) , rs2228145 (Hs)

CATH/Gene3D

2.60.40.10 (N/A)

ChEMBL Target

CHEMBL4289 (Rn) , CHEMBL2364155 (Hs)

关联配体

Ligand ID	7999
名称	sarilumab
别名	SAR153191
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sarilumab is a monoclonal antibody directed against the interleukin 6 receptor (IL6R). Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy and light chain variable regions of sarilumab provides 100% matches to sequences covered by patent US7582298 , and to the antibody with designation VQ8F11-21.
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参考文献

1. Strand V, Reaney M, Chen CI, Proudfoot CW, Guillonneau S, Bauer D, Mangan E, Graham NM, van Hoogstraten H, Lin Y et al.. (2017) Sarilumab improves patient-reported outcomes in rheumatoid arthritis patients with inadequate response/intolerance to tumour necrosis factor inhibitors.. RMD Open, 3 (1): (e000416). [PMID:28326189]
2. Boyapati A, Msihid J, Fiore S, van Adelsberg J, Graham NM, Hamilton JD. (2016) Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate: a biomarker study of MOBILITY.. Arthritis Res Ther, 18 (1): (225). [PMID:27716324]
3. Burmester GR, Lin Y, Patel R, van Adelsberg J, Mangan EK, Graham NM, van Hoogstraten H, Bauer D, Ignacio Vargas J, Lee EB. (2017) Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial.. Ann Rheum Dis, 76 (5): (840-847). [PMID:27856432]
4. Della-Torre E, Campochiaro C, Cavalli G, De Luca G, Napolitano A, La Marca S, Boffini N, Da Prat V, Di Terlizzi G, Lanzillotta M et al.. (2020) Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study.. Ann Rheum Dis, 79 (10): (1277-1285). [PMID:32620597]