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SB 328437（DMSO溶液）
高效选择性CCR3拮抗剂
- CAS编号: 247580-43-4
- 分子式: C21H18N2O5
- 分子量: 378.38
- PubChem编号: 10474776
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CCR3 Antagonist
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基本描述
| 英文名称 | SB 328437 (DMSO solution) |
|---|---|
| 别名 | N-(1-萘基羰基)-4-硝基-L-苯丙氨酸甲酯 |
| 英文别名 | SB 328437|247580-43-4|SB-328437|L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester|CHEMBL33227|methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate|methyl (2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate| |
| 储存温度 | 避光,-20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
在室温下运输。储存在-20℃。存放在黑暗中。存放在干燥的条件下。 Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions. |
名称和标识符
| IUPAC Name | methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate |
|---|---|
| INCHI | InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1 |
| InChi Key | VMFGCGRAIBLAFY-IBGZPJMESA-N |
| Canonical SMILES | COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32 |
| PubChem CID | 10474776 |
| 分子量 | 378.38 |
安全和危险性（GHS）
| 象形图 |
Environmental Hazard 
Harmful |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H302: Harmful if swallowed H400: Very toxic to aquatic life |
| 预防措施声明 | P273,P501,P264,P270,P391,P330,P301+P317 |
关联配体
| Ligand ID | 3530 |
|---|---|
| 名称 | SB328437 |
| 别名 | SB 328437 |
| 类别 | Synthetic organic |
| 学名 | methyl (2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | SB328437 is a potent and selective CCR3 antagonist. |
产品问答
产品问答
参考文献
| 1. Abonyo BO et al.. (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.. Am J Physiol Lung Cell Mol Physiol, 289 (3): (L478-88). [PMID:15863444] |
| 2. White JR et al.. (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.. J Biol Chem, 275 (47): (36626-31). [PMID:10969084] |
| 3. Mori A et al.. (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.. Int Immunol, 19 (8): (913-21). [PMID:17804691] |
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