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VEGFA

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp175377-500μg	500μg	期货
rp175377-1mg	1mg	期货

查看相关系列

fms related receptor tyrosine kinase 1 kinase insert domain receptor kinase insert domain receptor Agonist

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基本描述

产品名称	VEGFA

产品规格参数

CAS编号和信息	rp175377

数据库链接

UniProtKB	P15692
Wikipedia	VEGFA
RCSB PDB Structure	1bj1
Ensembl Gene	ENSG00000112715
DrugBank Target	P15692
CATH/Gene3D	2.10.160.10, 2.10.90.10

靶标

Target ID

1812

名称

fms related receptor tyrosine kinase 1

缩写名

VEGFR-1

家族

Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family

别名

EBRT2

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	1338	13q12.3	FLT1	fms related receptor tyrosine kinase 1
Mouse	1	1333	5 87.01 cM	Flt1	FMS-like tyrosine kinase 1
Rat	1	1336	12p11	Flt1	Fms related receptor tyrosine kinase 1

Ensembl Gene

ENSG00000102755 (Hs) , ENSMUSG00000029648 (Mm) , ENSRNOG00000000940 (Rn)

Entrez Gene

14254 (Mm) , 54251 (Rn) , 2321 (Hs)

OMIM

165070 (Hs)

Protein GI

11276093 (Rn) , 34328180 (Mm) , 229892302 (Hs)

UniProtKB

P17948 (Hs) , P35969 (Mm) , P53767 (Rn)

RefSeq Nucleotide

NM_001159920 (Hs) , NM_010228 (Mm) , NM_019306 (Rn)

RefSeq Protein

NP_001153392 (Hs) , NP_034358 (Mm) , NP_062179 (Rn)

DrugBank Target

P17948 (Hs)

CATH/Gene3D

2.60.40.10 (N/A)

ChEMBL Target

CHEMBL1868 (Hs) , CHEMBL3516 (Mm)

Target ID

1813

名称

kinase insert domain receptor

缩写名

VEGFR-2

家族

Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family

别名

EBRT2

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	1356	4q12	KDR	kinase insert domain receptor
Mouse	1	1367	5 40.23 cM	Kdr	kinase insert domain protein receptor
Rat	1	1343	14p11	Kdr	kinase insert domain receptor

Ensembl Gene

ENSG00000128052 (Hs) , ENSMUSG00000062960 (Mm) , ENSRNOG00000046829 (Rn)

Entrez Gene

16542 (Mm) , 25589 (Rn) , 3791 (Hs)

OMIM

191306 (Hs)

Protein GI

11321597 (Hs) , 27777648 (Mm) , 6981128 (Rn)

UniProtKB

P35968 (Hs) , P35918 (Mm) , O08775 (Rn)

RefSeq Nucleotide

NM_002253 (Hs) , NM_010612 (Mm) , NM_013062 (Rn)

RefSeq Protein

NP_002244 (Hs) , NP_034742 (Mm) , NP_037194 (Rn)

Orphanet

229801 (Hs)

DrugBank Target

P35968 (Hs)

CATH/Gene3D

2.60.40.10 (N/A)

ChEMBL Target

CHEMBL3337 (Mm) , CHEMBL279 (Hs)

关联配体

Ligand ID

5085

名称

VEGFA

别名

vascular permeability factor (VPF)

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

The active peptide is anti-parallel homodimer linked by disulphide bonds. VEGFA exists as four isoforms of 121, 165, 189 and 206 amino acids. The shortest variant contains the full VEGFR2 binding site but lacks domains that are involved in interactions with extracellular-matrix and co-receptors which are present in the longer isoforms .
A recombinant single-chain derivative of VEGFA121 (scVEGF) can be used experimentally as a fully functional peptide that binds and activates VEGFR2 in the same manner as endogenous VEGFA . scVEGF can be labelled with a single fluorophore at its N-terminal, for use as a molecular probe .

配体家族

Vascular endothelial growth factor (VEGF) family ligands

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
VEGFA	vascular endothelial growth factor A	prepro-vascular endothelial growth factor A	Human	VEGF, VEGF-A, VPF, vascular endothelial growth factor

单字母多肽序列

APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

三字母多肽序列

翻译后修饰

Homodimer formed by interchain disulphide bonds between cysteine residues at positions 51 and 60; further disulphide bonds formed between cysteine residues at positions 26 and 68, 57 and 102, and 61 and 104. Lysine residues at positions 121, 123 and 126 are N6-acetyllysine. N-linked glycosylation of asparagine residue at position 75

化学修饰

参考文献

1. Backer MV, Backer JM. (2001) Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteins.. Bioconjug Chem, 12 (6): (1066-73). [PMID:11716701]
2. Anderson CR, Rychak JJ, Backer M, Backer J, Ley K, Klibanov AL. (2010) scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis.. Invest Radiol, 45 (10): (579-85). [PMID:20733505]
3. Zachary IC. (2011) How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns.. Biochem Soc Trans, 39 (6): (1583-91). [PMID:22103491]
4. Vempati P, Popel AS, Mac Gabhann F. (2014) Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.. Cytokine Growth Factor Rev, 25 (1): (1-19). [PMID:24332926]