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基本描述
| 产品名称 | TWEAK |
|---|
产品规格参数
| CAS编号和信息 | rp175337 |
|---|
数据库链接
| UniProtKB | O43508 |
|---|---|
| Wikipedia | TNFSF12 |
| Ensembl Gene | ENSG00000239697 |
| CATH/Gene3D | 2.60.120.40 |
靶标
| Target ID | 1884 | ||||||||||||||||||||||||
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| 名称 | TWEAK receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000006327 (Hs) , ENSMUSG00000023905 (Mm) , ENSRNOG00000003546 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 27279 (Mm) , 302965 (Rn) , 51330 (Hs) | ||||||||||||||||||||||||
| OMIM | 605914 (Hs) | ||||||||||||||||||||||||
| Protein GI | 7706186 (Hs) , 239915999 (Mm) , 30842836 (Rn) | ||||||||||||||||||||||||
| UniProtKB | Q9NP84 (Hs) , Q9CR75 (Mm) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3712850 (Hs) |
关联配体
| Ligand ID | 5067 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | TWEAK | ||||||||||
| 别名 | TNF-related weak inducer of apoptosis | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | TWEAK protein (TNFSF12) is a tumor necrosis factor (TNF) family cytokine that exists in both membrane-bound and secreted forms. It acts via interaction with the TWEAK receptor (encoded by the TNFRSF12A gene), and is a modulator of endothelial cell proliferation and migration, and is therefore an angiogenesis regulator. | ||||||||||
| 配体家族 | Tumor necrosis factor superfamily ligands | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | |||||||||||
| 化学修饰 |
产品问答
产品问答
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