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RANK ligand
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基本描述
| 产品名称 | RANK ligand |
|---|
产品规格参数
| CAS编号和信息 | rp174879 |
|---|
数据库链接
| UniProtKB | O14788 |
|---|---|
| Wikipedia | RANKL |
| RCSB PDB Structure | 1JTZ |
| Ensembl Gene | ENSG00000120659 |
| Protein GI | 4507595 |
| DrugBank Target | O14788 |
| CATH/Gene3D | 2.60.120.40 |
| Immunopaedia Search | RANK ligand |
靶标
| Target ID | 1881 | ||||||||||||||||||||||||
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| 名称 | receptor activator of NF-kappa B | ||||||||||||||||||||||||
| 缩写名 | RANK | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000141655 (Hs) , ENSMUSG00000026321 (Mm) , ENSRNOG00000015615 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 21934 (Mm) , 498206 (Rn) , 8792 (Hs) | ||||||||||||||||||||||||
| OMIM | 603499 (Hs) | ||||||||||||||||||||||||
| Protein GI | 4507565 (Hs) , 110350009 (Mm) , 109498476 (Rn) | ||||||||||||||||||||||||
| UniProtKB | Q9Y6Q6 (Hs) , O35305 (Mm) |
关联配体
| Ligand ID | 5066 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | RANK ligand | ||||||||||
| 别名 | receptor activator of nuclear factor κB ligand | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | RANK ligand (TNFSF11) is a member of the tumor necrosis factor (TNF) cytokine family. It can exist in both membrane-bound and soluble forms. It is a key factor for osteoclast differentiation and activation. Osteoprotegerin acts as a decoy receptor for RANK ligand. | ||||||||||
| 配体家族 | CD molecules (ligands) | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted N-linked glycosyaltion of asparagine residues at positions 171 and 198 | ||||||||||
| 化学修饰 |
产品问答
产品问答
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