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基本描述
| 产品名称 | OX-40 ligand |
|---|
产品规格参数
| CAS编号和信息 | rp174706 |
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数据库链接
| UniProtKB | P23510 |
|---|---|
| Wikipedia | OX40L |
| RCSB PDB Structure | 2HEV |
| Ensembl Gene | ENSG00000117586 |
靶标
| Target ID | 1873 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | OX40 | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000186827 (Hs) , ENSMUSG00000029075 (Mm) , ENSRNOG00000020106 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 22163 (Mm) , 25572 (Rn) , 7293 (Hs) | ||||||||||||||||||||||||
| OMIM | 600315 (Hs) | ||||||||||||||||||||||||
| Protein GI | 6981688 (Rn) , 6755909 (Mm) , 4507579 (Hs) | ||||||||||||||||||||||||
| UniProtKB | P43489 (Hs) , P15725 (Rn) , P47741 (Mm) | ||||||||||||||||||||||||
| RefSeq Protein | NP_035789 (Mm) , NP_003318 (Hs) , NP_037181 (Rn) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_011659 (Mm) , NM_003327 (Hs) , NM_013049 (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3989383 (Hs) |
关联配体
| Ligand ID | 5076 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | OX-40 ligand | ||||||||||
| 别名 | glycoprotein Gp34 | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
OX40L is overexpressed in B cells, T cells, and fibroblasts in fibrotic skin of patients with systemic sclerosis (SSc) |
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| 评价 |
OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models An antibody binding mouse OX40L |
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| 配体家族 | CD molecules (ligands) | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | N-linked glycosylation of asparagine residue at position 152; predicted N-linked glycosylation of asparagines at positions 90, 114 and 157; disulphide bond formation between cysteine residues at positions 97 and 181 | ||||||||||
| 化学修饰 |
参考文献
| 1. Komura K, Yoshizaki A, Kodera M, Iwata Y, Ogawa F, Shimizu K, Wayaku T, Yukami T, Murata M, Hasegawa M et al.. (2008) Increased serum soluble OX40 in patients with systemic sclerosis.. J Rheumatol, 35 (12): (2359-62). [PMID:18843780] |
| 2. Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC et al.. (2014) OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.. Proc Natl Acad Sci USA, 111 (6): (2289-94). [PMID:24469824] |
| 3. Webb GJ, Hirschfield GM, Lane PJ. (2016) OX40, OX40L and Autoimmunity: a Comprehensive Review.. Clin Rev Allergy Immunol, 50 (3): (312-32). [PMID:26215166] |
| 4. Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A et al.. (2016) OX40L blockade protects against inflammation-driven fibrosis.. Proc Natl Acad Sci USA, 113 (27): (E3901-10). [PMID:27298374] |
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