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LIGHT

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp174461-500μg	500μg	期货
rp174461-1mg	1mg	期货

查看相关系列

herpes virus entry mediator lymphotoxin β receptor

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基本描述

产品名称	LIGHT

产品规格参数

CAS编号和信息	rp174461

数据库链接

UniProtKB	O43557
Wikipedia	TNFSF14
RCSB PDB Structure	3UGN
Ensembl Gene	ENSG00000125735
CATH/Gene3D	2.60.120.40

靶标

Target ID

1872

名称

lymphotoxin β receptor

缩写名

SHP2

家族

Tumour necrosis factor (TNF) receptor family

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	435	12p13.31	LTBR	lymphotoxin beta receptor
Mouse	1	415	6 59.32 cM	Ltbr	lymphotoxin B receptor
Rat	2	147	18p11	Ltbr	lymphotoxin beta receptor

Ensembl Gene

ENSG00000111321 (Hs) , ENSMUSG00000030339 (Mm) , ENSRNOG00000019264 (Rn)

Entrez Gene

17000 (Mm) , 297604 (Rn) , 4055 (Hs)

OMIM

600979 (Hs)

Protein GI

4505039 (Hs) , 7549775 (Mm) , 56605710 (Rn)

UniProtKB

P36941 (Hs) , P50284 (Mm)

ChEMBL Target

CHEMBL1250360 (Hs)

Target ID

1887

名称

herpes virus entry mediator

缩写名

HVEM

家族

Immune checkpoint catalytic receptors

别名

SK3

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	283	1p36.32	TNFRSF14	TNF receptor superfamily member 14
Mouse	2	147	18p11	Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat	2	147	18p11	Tnfrsf14	TNF receptor superfamily member 14

Ensembl Gene

ENSG00000157873 (Hs) , ENSMUSG00000042333 (Mm) , ENSRNOG00000013820 (Rn)

Entrez Gene

230979 (Mm) , 366518 (Rn) , 8764 (Hs)

OMIM

602746 (Hs)

Protein GI

23200041 (Hs) , 62543557 (Rn) , 30725810 (Mm)

UniProtKB

Q92956 (Hs)

关联配体

Ligand ID

5070

名称

LIGHT

别名

TR2

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes . It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).

配体家族

CD molecules (ligands)

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
TNFSF14	TNF superfamily member 14	prepro-tumor necrosis factor ligand superfamily member 14	Human	LIGHT, LTg, HVEM-L, CD258, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor superfamily member 14

单字母多肽序列

MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV

三字母多肽序列

翻译后修饰

N-linked glycosylation of asparagine residue at position 102; predicted disulphide bond between cysteine resisues at positons 154 and 187

化学修饰

参考文献

1. Cohavy O, Zhou J, Ware CF, Targan SR. (2005) LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.. J Immunol, 174 (2): (646-53). [PMID:15634882]
2. Ware CF. (2005) Network communications: lymphotoxins, LIGHT, and TNF.. Annu Rev Immunol, 23 (13): (787-819). [PMID:15771586]