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药物靶标
G蛋白偶联受体（GPCR）
糖蛋白激素受体
Recombinant Human LH alpha/beta Heterodimer Protein

Recombinant Human LH alpha/beta Heterodimer Protein

规格或纯度: Carrier Free, >90% (SDS-PAGE), E.coli, N-His tag, 25-116 aa & 21-141 aa

蛋白标签: N-His tag

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货号 (SKU)	包装规格	是否现货
rp174456-10μg	10μg	期货
rp174456-100μg	100μg	期货
rp174456-1mg	1mg	期货
rp174456-500μg	500μg	期货

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LH receptor Agonist

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基本描述

产品名称	Recombinant Human LH alpha/beta Heterodimer Protein
规格或纯度	Carrier Free, >90% (SDS-PAGE), E.coli, N-His tag, 25-116 aa & 21-141 aa
产品介绍	Purity >90% SDS-PAGE. Background: Luteinizing Hormone (LH) is a 42 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit (CG alpha ) is also a component of Follicle-Stimulating Hormone (FSH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with its receptor. The approximately 20 kDa human CG alpha subunit shares 73% and 72% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The approximately 18 kDa human LH beta subunit shares 71% and 72% aa sequence identity with the mouse and rat orthologs, respectively. Multiple isoforms of LH exist due to differences in the post-translational glycosylation, sialylation, and sulphation modifications of its subunits. The composition, longevity, and activity of the different LH isoforms vary throughout a woman’s menstrual cycle and reproductive life cycle. LH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, LH secretion can also be stimulated by estradiol. LH works in concert with FSH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation. LH also drives formation of the corpus luteum by promoting progesterone production. Additionally, LH has been suggested to stimulate the adrenal gland in postmenopausal women to induce secretion of sulfated DHEA, a precursor to androgens. In the testis, LH induces Leydig cell production of testosterone. Hypersecretion of LH has been shown to occur in women with polycystic ovary syndrome and is associated with an increased risk of infertility and miscarriage. Additionally, increased serum LH levels are associated with decreased cognition and have been implicated in the development and progression of Alzheimer’s disease. receptor into an A-frame.
氨基酸	25-116 aa & 21-141 aa
序列	APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSGGGGSGGGGSGGGGSSREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
蛋白标签	N-His tag
预测分子量	28 kDa
SDS-PAGE	43 kDa under reducing conditions

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 0.01% SKL, pH7.4.
复溶	Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 2-8℃ for one month. Aliquot and store at -80℃ for 12 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	rp174456

数据库链接

Wikipedia	Luteinising_hormone
PEP	lh

靶标

Target ID

254

名称

LH receptor

缩写名

SHP2

家族

Glycoprotein hormone receptors

别名

adrenergic receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	700	6q12	Lhcgr	luteinizing hormone/choriogonadotropin receptor
Human	7	699	2p16.3	LHCGR	luteinizing hormone/choriogonadotropin receptor
Mouse	7	700	17 58.35 cM	Lhcgr	luteinizing hormone/choriogonadotropin receptor

RefSeq Protein

NP_037110 (Rn) , NP_000224 (Hs) , NP_038610 (Mm)

UniProtKB

P16235 (Rn) , P22888 (Hs) , P30730 (Mm)

OMIM

152790 (Hs)

RefSeq Nucleotide

NM_000233 (Hs) , NM_012978 (Rn) , NM_013582 (Mm)

Entrez Gene

3973 (Hs) , 25477 (Rn) , 16867 (Mm)

Ensembl Gene

ENSG00000138039 (Hs) , ENSMUSG00000024107 (Mm) , ENSRNOG00000016712 (Rn)

Orphanet

123048 (Hs)

Protein GI

6981160 (Rn) , 7305233 (Mm) , 106067657 (Hs)

GPCRdb

lshr_human (Hs) , lshr_mouse (Mm) , lshr_rat (Rn)

UniProtKB ID/Entry name

LSHR_HUMAN (Hs) , LSHR_MOUSE (Mm) , LSHR_RAT (Rn)

DrugBank Target

P22888 (Hs)

CATH/Gene3D

3.80.10.10 (N/A)

ChEMBL Target

CHEMBL4523213 (Mm) , CHEMBL1854 (Hs) , CHEMBL2456 (Rn)

关联配体

Ligand ID	1159
名称	LH
别名	luteinising hormone
类别	Peptide
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	The approved drug lutropin alfa (INN) is the recombinant form of human LH and is composed of two subunits (α = 92 amino acids, β = 121 amino acids).
配体家族	Glycoprotein hormones
相似的配体	LH , LH
单字母多肽序列
三字母多肽序列
翻译后修饰	The production of biologically active LH requires appropriately folded and glycosylated LHβ and common α subunits that assemble to form the active LH heterodimer .
化学修饰