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基本描述
| 产品名称 | LH |
|---|
产品规格参数
| CAS编号和信息 | rp174454 |
|---|
数据库链接
| ChEMBL Ligand | CHEMBL1201419 |
|---|---|
| GPCRdb Ligand | LH |
靶标
| Target ID | 254 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | LH receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Glycoprotein hormone receptors | ||||||||||||||||||||||||
| 别名 | adrenergic receptor | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
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| RefSeq Protein | NP_037110 (Rn) , NP_000224 (Hs) , NP_038610 (Mm) | ||||||||||||||||||||||||
| UniProtKB | P16235 (Rn) , P22888 (Hs) , P30730 (Mm) | ||||||||||||||||||||||||
| OMIM | 152790 (Hs) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_000233 (Hs) , NM_012978 (Rn) , NM_013582 (Mm) | ||||||||||||||||||||||||
| Entrez Gene | 3973 (Hs) , 25477 (Rn) , 16867 (Mm) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000138039 (Hs) , ENSMUSG00000024107 (Mm) , ENSRNOG00000016712 (Rn) | ||||||||||||||||||||||||
| Orphanet | 123048 (Hs) | ||||||||||||||||||||||||
| Protein GI | 6981160 (Rn) , 7305233 (Mm) , 106067657 (Hs) | ||||||||||||||||||||||||
| GPCRdb | lshr_human (Hs) , lshr_mouse (Mm) , lshr_rat (Rn) | ||||||||||||||||||||||||
| UniProtKB ID/Entry name | LSHR_HUMAN (Hs) , LSHR_MOUSE (Mm) , LSHR_RAT (Rn) | ||||||||||||||||||||||||
| DrugBank Target | P22888 (Hs) | ||||||||||||||||||||||||
| CATH/Gene3D | 3.80.10.10 (N/A) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL4523213 (Mm) , CHEMBL1854 (Hs) , CHEMBL2456 (Rn) |
关联配体
| Ligand ID | 1159 |
|---|---|
| 名称 | LH |
| 别名 | luteinising hormone |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | The approved drug lutropin alfa (INN) is the recombinant form of human LH and is composed of two subunits (α = 92 amino acids, β = 121 amino acids). |
| 配体家族 | Glycoprotein hormones |
| 相似的配体 | LH , LH |
| 单字母多肽序列 | |
| 三字母多肽序列 | |
| 翻译后修饰 |
The production of biologically active LH requires appropriately folded and glycosylated LHβ and common α subunits that assemble to form the active LH heterodimer |
| 化学修饰 |
参考文献
| 1. Bousfield GR, Dias JA. (2011) Synthesis and secretion of gonadotropins including structure-function correlates.. Rev Endocr Metab Disord, 12 (4): (289-302). [PMID:21739108] |
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产品问答
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