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IL-7
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基本描述
| 产品名称 | IL-7 |
|---|
产品规格参数
| CAS编号和信息 | rp174315 |
|---|
数据库链接
| UniProtKB | P13232 |
|---|---|
| Wikipedia | Interleukin_7 |
| Ensembl Gene | ENSG00000104432 |
靶标
| Target ID | 2300 |
|---|---|
| 名称 | Interleukin-7 receptor |
| 缩写名 | SHP2 |
| 家族 | IL-2 receptor family |
| 别名 | MAS1 oncogene-like |
关联配体
| Ligand ID | 4999 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IL-7 | ||||||||||
| 别名 | interleukin-7 | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | IL-7 is produced primarily by stromal cells and exerts its effects via a receptor complex consisting of IL-7 receptor alpha (IL7R) and a common IL-2 receptor gamma subunit (IL2RG). IL-7 signaling is essential for the establishment and maintenance of normal immune system functions. IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T cells. | ||||||||||
| 配体家族 | Interleukins | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | DCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Disulphide bond formation between cysteine residues at positions 2 and 141, 24 and 129, and 47 and 92, predicted N-linked glycosylation of asparagine residues at positions 70, 91 and 116 | ||||||||||
| 化学修饰 |
参考文献
| 1. Lin J, Zhu Z, Xiao H, Wakefield MR, Ding VA, Bai Q, Fang Y. (2017) The role of IL-7 in Immunity and Cancer.. Anticancer Res, 37 (3): (963-967). [PMID:28314253] |
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