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IL-36 receptor antagonist
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基本描述
| 产品名称 | IL-36 receptor antagonist |
|---|
产品规格参数
| CAS编号和信息 | rp174310 |
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数据库链接
| UniProtKB | Q9UBH0 |
|---|---|
| Ensembl Gene | ENSG00000136695 |
| Wikipedia | IL1F5 |
靶标
| Target ID | 1907 |
|---|---|
| 名称 | Interleukin-36 receptor |
| 缩写名 | SHP2 |
| 家族 | Immunoglobulin-like family of IL-1 receptors |
| 别名 | GPR167 |
关联配体
| Ligand ID | 5879 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IL-36 receptor antagonist | ||||||||||
| 别名 | interleukin 1 family member 5 (delta) | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 |
IL-36 receptor antagonist is also known as IL-36RA or IL36RN, the latter being the gene symbol. It acts by antagonising the binding of IL-36α, β and γ to interleukin 1 receptor like 2 (IL1RL2) which is the ligand binding component of the functional IL-36 receptor. Abnormailites in the IL36RN gene that produce mutated IL-36RA protein structures with compromised function have been identified as a cause of unregulated inflammatory cytokine secretion which drives the repeated inflammatory episodes that characterise the life-threatening condition, generalized pustular psoriasis |
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| 配体家族 | Interleukins | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD | ||||||||||
| 三字母多肽序列 | Met-Val-Leu-Ser-Gly-Ala-Leu-Cys-Phe-Arg-Met-Lys-Asp-Ser-Ala-Leu-Lys-Val-Leu-Tyr-Leu-His-Asn-Asn-Gln-Leu-Leu-Ala-Gly-Gly-Leu-His-Ala-Gly-Lys-Val-Ile-Lys-Gly-Glu-Glu-Ile-Ser-Val-Val-Pro-Asn-Arg-Trp-Leu-Asp-Ala-Ser-Leu-Ser-Pro-Val-Ile-Leu-Gly-Val-Gln-Gly-Gly-Ser-Gln-Cys-Leu-Ser-Cys-Gly-Val-Gly-Gln-Glu-Pro-Thr-Leu-Thr-Leu-Glu-Pro-Val-Asn-Ile-Met-Glu-Leu-Tyr-Leu-Gly-Ala-Lys-Glu-Ser-Lys-Ser-Phe-Thr-Phe-Tyr-Arg-Arg-Asp-Met-Gly-Leu-Thr-Ser-Ser-Phe-Glu-Ser-Ala-Ala-Tyr-Pro-Gly-Trp-Phe-Leu-Cys-Thr-Val-Pro-Glu-Ala-Asp-Gln-Pro-Val-Arg-Leu-Thr-Gln-Leu-Pro-Glu-Asn-Gly-Gly-Trp-Asn-Ala-Pro-Ile-Thr-Asp-Phe-Tyr-Phe-Gln-Gln-Cys-Asp | ||||||||||
| 翻译后修饰 | Predicted disulphide bond formation between cysteinen residues at positions 8 and 154. | ||||||||||
| 化学修饰 |
参考文献
| 1. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE. (1999) IL1HY1: A novel interleukin-1 receptor antagonist gene.. Biochem Biophys Res Commun, 263 (3): (702-6). [PMID:10512743] |
| 2. Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M et al.. (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.. N Engl J Med, 365 (7): (620-8). [PMID:21848462] |
| 3. Abbas O, Itani S, Ghosn S, Kibbi AG, Fidawi G, Farooq M, Shimomura Y, Kurban M. (2013) Acrodermatitis continua of Hallopeau is a clinical phenotype of DITRA: evidence that it is a variant of pustular psoriasis.. Dermatology (Basel), 226 (1): (28-31). [PMID:23428889] |
| 4. Kanazawa N, Nakamura T, Mikita N, Furukawa F. (2013) Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis.. J Dermatol, 40 (9): (749-51). [PMID:23834760] |
| 5. Gresnigt MS, van de Veerdonk FL. (2013) Biology of IL-36 cytokines and their role in disease.. Semin Immunol, 25 (6): (458-65). [PMID:24355486] |
| 6. Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, Zenati A, Makrelouf M, Boubridaa K, Chiali A et al.. (2016) IL36RN Mutations Affect Protein Expression?and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases.. J Invest Dermatol, 136 (9): (1811-9). [PMID:27220475] |
| 7. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al.. (2017) Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.. MAbs, 9 (7): (1143-1154). [PMID:28726542] |
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