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IL-36α
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基本描述
| 产品名称 | IL-36α |
|---|
产品规格参数
| CAS编号和信息 | rp174307 |
|---|
数据库链接
| UniProtKB | Q9UHA7 |
|---|---|
| Ensembl Gene | ENSG00000136694 |
| Wikipedia | IL36A |
靶标
| Target ID | 1907 |
|---|---|
| 名称 | Interleukin-36 receptor |
| 缩写名 | SHP2 |
| 家族 | Immunoglobulin-like family of IL-1 receptors |
| 别名 | GPR167 |
关联配体
| Ligand ID | 5881 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IL-36α | ||||||||||
| 别名 | FIL1 epsilon | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist form the IL-36 group of cytokines and are a subset of the IL-1 cytokine family. IL-36α, IL-36β, IL-36γ are agonists of the IL-36 receptor complex (IL1RL2/IL1R-rp2/IL-36 receptor) and activate NF-κB and MAP kinase pathways inducing a pro-inflammatory response. The IL-36 receptor antagonist as its name suggests antagonises signalling by the IL-36 receptor agonists to reduce their pro-inflammatory function. | ||||||||||
| 配体家族 | Interleukins | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF | ||||||||||
| 三字母多肽序列 | Met-Glu-Lys-Ala-Leu-Lys-Ile-Asp-Thr-Pro-Gln-Gln-Gly-Ser-Ile-Gln-Asp-Ile-Asn-His-Arg-Val-Trp-Val-Leu-Gln-Asp-Gln-Thr-Leu-Ile-Ala-Val-Pro-Arg-Lys-Asp-Arg-Met-Ser-Pro-Val-Thr-Ile-Ala-Leu-Ile-Ser-Cys-Arg-His-Val-Glu-Thr-Leu-Glu-Lys-Asp-Arg-Gly-Asn-Pro-Ile-Tyr-Leu-Gly-Leu-Asn-Gly-Leu-Asn-Leu-Cys-Leu-Met-Cys-Ala-Lys-Val-Gly-Asp-Gln-Pro-Thr-Leu-Gln-Leu-Lys-Glu-Lys-Asp-Ile-Met-Asp-Leu-Tyr-Asn-Gln-Pro-Glu-Pro-Val-Lys-Ser-Phe-Leu-Phe-Tyr-His-Ser-Gln-Ser-Gly-Arg-Asn-Ser-Thr-Phe-Glu-Ser-Val-Ala-Phe-Pro-Gly-Trp-Phe-Ile-Ala-Val-Ser-Ser-Glu-Gly-Gly-Cys-Pro-Leu-Ile-Leu-Thr-Gln-Glu-Leu-Gly-Lys-Ala-Asn-Thr-Thr-Asp-Phe-Gly-Leu-Thr-Met-Leu-Phe | ||||||||||
| 翻译后修饰 | Tyrosine residue at position 96 is nitrated. | ||||||||||
| 化学修饰 |
参考文献
| 1. Gresnigt MS, van de Veerdonk FL. (2013) Biology of IL-36 cytokines and their role in disease.. Semin Immunol, 25 (6): (458-65). [PMID:24355486] |
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