首页
400-620-6333
IL-34
有货
切换导航
搜索
基本描述
| 产品名称 | IL-34 |
|---|
产品规格参数
| CAS编号和信息 | rp174306 |
|---|
靶标
| Target ID | 1806 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | colony stimulating factor 1 receptor | ||||||||||||||||||||||||
| 缩写名 | CSFR | ||||||||||||||||||||||||
| 家族 | Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family | ||||||||||||||||||||||||
| 别名 | mrgG | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| Ensembl Gene | ENSG00000182578 (Hs) , ENSMUSG00000024621 (Mm) , ENSRNOG00000018414 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 12978 (Mm) , 307403 (Rn) , 1436 (Hs) | ||||||||||||||||||||||||
| OMIM | 164770 (Hs) | ||||||||||||||||||||||||
| Protein GI | 71361659 (Rn) , 27262659 (Hs) , 126723423 (Mm) | ||||||||||||||||||||||||
| UniProtKB | P07333 (Hs) , P09581 (Mm) , Q00495 (Rn) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_001029901 (Rn) , NM_001037859 (Mm) , NM_005211 (Hs) | ||||||||||||||||||||||||
| RefSeq Protein | NP_001025072 (Rn) , NP_001032948 (Mm) , NP_005202 (Hs) | ||||||||||||||||||||||||
| Orphanet | 317674 (Hs) | ||||||||||||||||||||||||
| CATH/Gene3D | 2.60.40.10 (N/A) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL1844 (Hs) , CHEMBL5570 (Mm) |
关联配体
| Ligand ID | 8975 |
|---|---|
| 名称 | IL-34 |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
IL-34-induced increase in monocyte viability is inhibited by the CSF1R inhibitor |
| 评价 |
IL-34 is an endogenous ligand of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R) |
| 配体家族 | Interleukins |
| 单字母多肽序列 | MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP |
| 三字母多肽序列 | |
| 翻译后修饰 | 1-20 is the signal peptide, 21-242 is the ligand sequence. N-linked glycosylation at position 76. |
| 化学修饰 |
参考文献
| 1. Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D et al.. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.. Science, 320 (5877): (807-11). [PMID:18467591] |
| 2. Chang EJ, Lee SK, Song YS, Jang YJ, Park HS, Hong JP, Ko AR, Kim DY, Kim JH, Lee YJ et al.. (2014) IL-34 is associated with obesity, chronic inflammation, and insulin resistance.. J Clin Endocrinol Metab, 99 (7): (E1263-71). [PMID:24712570] |
| 3. Franzè E, Monteleone I, Cupi ML, Mancia P, Caprioli F, Marafini I, Colantoni A, Ortenzi A, Laudisi F, Sica G et al.. (2015) Interleukin-34 sustains inflammatory pathways in the gut.. Clin Sci, 129 (3): (271-80). [PMID:25800277] |
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）