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IL-31
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基本描述
| 产品名称 | IL-31 |
|---|
产品规格参数
| CAS编号和信息 | rp174304 |
|---|
数据库链接
| UniProtKB | Q6EBC2 |
|---|---|
| Wikipedia | Interleukin_31 |
| Ensembl Gene | ENSG00000204671 |
靶标
| Target ID | 2312 |
|---|---|
| 名称 | Interleukin-31 receptor |
| 缩写名 | SHP2 |
| 家族 | IL-6 receptor family |
关联配体
| Ligand ID | 4995 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IL-31 | ||||||||||
| 别名 | interleukin-31 | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | IL-31 is an IL-6 family cytokine. | ||||||||||
| 配体家族 | Interleukins | ||||||||||
| 基因/前体 |
|
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| 单字母多肽序列 | SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted N-linked glycosylation of asparagine residues at positions 44 and 77 | ||||||||||
| 化学修饰 |
参考文献
| 1. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J et al.. (2006) IL-31: a new link between T cells and pruritus in atopic skin inflammation.. J Allergy Clin Immunol, 117 (2): (411-7). [PMID:16461142] |
| 2. Lee CH, Yu HS. (2011) Biomarkers for itch and disease severity in atopic dermatitis.. Curr Probl Dermatol, 41 (13): (136-48). [PMID:21576954] |
| 3. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. (2012) Signaling by IL-31 and functional consequences.. Eur J Cell Biol, 91 (6-7): (552-66). [PMID:21982586] |
| 4. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM. (2011) IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis.. Ann Dermatol, 23 (4): (468-73). [PMID:22148014] |
| 5. Baron JM, Lüscher B. (2012) IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis.. Acta Derm Venereol, 92 (1): (5-6). [PMID:22215012] |
| 6. Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC et al.. (2017) Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.. J Eur Acad Dermatol Venereol, 31 (1): (142-150). [PMID:27501029] |
| 7. Storan ER, O'Gorman SM, McDonald ID, Steinhoff M. (2015) Role of cytokines and chemokines in itch.. Handb Exp Pharmacol, 226 (13): (163-76). [PMID:25861779] |
| 8. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al.. (2016) The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.. Br J Dermatol, 174 (2): (296-304). [PMID:26409172] |
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