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IL-1α
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基本描述
| 产品名称 | IL-1α |
|---|
产品规格参数
| CAS编号和信息 | rp174289 |
|---|
数据库链接
| UniProtKB | P01583 |
|---|---|
| Wikipedia | Interleukin_1 |
| RCSB PDB Structure | 2ila |
| Ensembl Gene | ENSG00000115008 |
靶标
| Target ID | 1905 |
|---|---|
| 名称 | Interleukin-1 receptor, type I |
| 缩写名 | SHP2 |
| 家族 | Immunoglobulin-like family of IL-1 receptors |
| 别名 | GPR167 |
关联配体
| Ligand ID | 4973 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IL-1α | ||||||||||
| 别名 | interleukin-1 alpha | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
||||||||||
| 评价 | IL-1α is an IL-1 family cytokine. | ||||||||||
| 配体家族 | Interleukins | ||||||||||
| 基因/前体 |
|
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| 单字母多肽序列 | SAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted N-linked glycosylation of asparagine at position 29 | ||||||||||
| 化学修饰 |
参考文献
| 1. Hong DS, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P et al.. (2015) Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer.. Invest New Drugs, 33 (3): (621-31). [PMID:25822109] |
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