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IFN-α2
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基本描述
| 产品名称 | IFN-α2 |
|---|
产品规格参数
| CAS编号和信息 | rp174255 |
|---|
数据库链接
| UniProtKB | P01563 |
|---|---|
| Wikipedia | IFNA2 |
| RCSB PDB Structure | 1itf |
| Ensembl Gene | ENSG00000188379 |
| IMGT/mAb-DB | 624 |
靶标
| Target ID | 1898 |
|---|---|
| 名称 | Interferon-α/β receptor |
| 缩写名 | SHP2 |
| 家族 | Interferon receptor family |
| 别名 | MAS-related GPR, member E |
关联配体
| Ligand ID | 4960 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | IFN-α2 | ||||||||||
| 别名 | IFN-alpha-2 | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 | IFN-α2 binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements. | ||||||||||
| 评价 |
IFN-α2 is a type I IFN. The sequence of the recombinant peptide used clinically and known as interferon alfa-2a, is identical to that of human IFN-α2. Interferon α-2a has anti-viral, immunomodulatory and antineoplastic actions. Pegylated IFN-α-2a is on the World Health Organization's List of Essential Medicines. |
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| 配体家族 | Interferons | ||||||||||
| 基因/前体 |
|
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| 单字母多肽序列 | CDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | O-linked glycosylation of threonine residue at position 106; disulphide bond between cysteine residues at positions 1 and 98, and 29 and 138 | ||||||||||
| 化学修饰 |
产品问答
产品问答
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