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基本描述
| 产品名称 | GLP-2 analogue 10 |
|---|
产品规格参数
| CAS编号和信息 | rp174140 |
|---|
数据库链接
| GPCRdb Ligand | GLP-2 analogue 10 |
|---|
关联配体
| Ligand ID | 9896 |
|---|---|
| 名称 | GLP-2 analogue 10 |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
GLP-2 analogue 10 exhibits more effective anti-inflammatory effects in mouse models of DSS-induced colitis than |
| 评价 |
This GLP-2 analogue (peptide 10 in The intestinotrophic effects of GLP-2 (e.g. promotion of intestinal growth, reduced epithelial cell apoptosis and inflammation) has led to the development of GLP-2 analogues for the treatment of GI disorders such as short bowel syndrome, inflammatory bowel diseases and potentially other intestinal insufficiency diseases. |
| 单字母多肽序列 | HGDGSFSDEMCTILDNLCARDFINWLIQTKITDPSSGAPPPS-NH2 |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
Cys residues 11 and 18 are covalently linked by the lipidated cross-linker L3 which contains a cysteine-reactive bis-bromoacetamide moiety |
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产品问答
参考文献
| 1. Blonski W, Buchner AM, Aberra F, Lichtenstein G. (2013) Teduglutide in Crohn's disease.. Expert Opin Biol Ther, 13 (8): (1207-14). [PMID:23834252] |
| 2. Kochar B, Long MD, Shelton E, Young L, Farraye FA, Yajnik V, Herfarth H. (2017) Safety and Efficacy of Teduglutide (Gattex) in Patients With Crohn's Disease and Need for Parenteral Support Due to Short Bowel Syndrome-associated Intestinal Failure.. J Clin Gastroenterol, 51 (6): (508-511). [PMID:27433811] |
| 3. Yang PY, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W. (2018) Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models.. J Med Chem, 61 (7): (3218-3223). [PMID:29528634] |
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