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GE-137
功能和特点
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基本描述
| 产品名称 | GE-137 |
|---|
产品规格参数
| CAS编号和信息 | rp174125 |
|---|
数据库链接
| UniParc | UPI0001950C0D |
|---|---|
| PubChem CID | 91827375 |
关联配体
| Ligand ID | 8585 |
|---|---|
| 名称 | GE-137 |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
GE-137 is a cyclic peptide constructed as a fluorescent probe for the detection of colorectal polyps by binding to human tyrosine kinase c-Met |
| 单字母多肽序列 | AGSCYCSGPPRFECWCYETEGTGGGK |
| 三字母多肽序列 | Ala-Gly-Ser-Cys-Tyr-Cys-Ser-Gly-Pro-Pro-Arg-Phe-Glu-Cys-Trp-Cys-Tyr-Glu-Thr-Glu-Gly-Thr-Gly-Gly-Gly-Lys |
| 翻译后修饰 | |
| 化学修饰 |
Has fluorescent cyanine dye Cy5** (PubChem CID 58490236) attached by the linker GGGK at the C-terminal |
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参考文献
| 1. Burggraaf J, Kamerling IM, Gordon PB, Schrier L, de Kam ML, Kales AJ, Bendiksen R, Indrevoll B, Bjerke RM, Moestue SA et al.. (2015) Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met.. Nat Med, 21 (8): (955-61). [PMID:26168295] |
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