首页
400-620-6333
切换导航
搜索
基本描述
| 产品名称 | Fas ligand |
|---|
产品规格参数
| CAS编号和信息 | rp173993 |
|---|
数据库链接
| UniProtKB | P48023 |
|---|---|
| Wikipedia | CD95L |
| Ensembl Gene | ENSG00000117560 |
| CATH/Gene3D | 2.60.120.40 |
靶标
| Target ID | 1875 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | Fas | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| Ensembl Gene | ENSG00000026103 (Hs) , ENSMUSG00000024778 (Mm) , ENSRNOG00000019142 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 14102 (Mm) , 246097 (Rn) , 355 (Hs) | ||||||||||||||||||||||||
| OMIM | 134637 (Hs) | ||||||||||||||||||||||||
| Protein GI | 59624977 (Rn) , 23510423 (Hs) , 226443053 (Mm) | ||||||||||||||||||||||||
| UniProtKB | P25445 (Hs) , P25446 (Mm) , Q63199 (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL2417350 (Rn) , CHEMBL4523207 (Hs) |
关联配体
| Ligand ID | 5078 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | Fas ligand | ||||||||||
| 别名 | CD95L | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
||||||||||
| 评价 | The TNFSF6 precursor is also cleaved into a soluble form of the ligand. | ||||||||||
| 配体家族 | CD molecules (ligands) | ||||||||||
| 基因/前体 |
|
||||||||||
| 单字母多肽序列 | MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted N-linked glycosylation of asparagine residues at positions 184, 250 and 260; predicted disulphide bond formation between cysteine residues at positions 202 and 233 | ||||||||||
| 化学修饰 |
参考文献
| 1. Bidère N, Su HC, Lenardo MJ. (2006) Genetic disorders of programmed cell death in the immune system.. Annu Rev Immunol, 24 (13): (321-52). [PMID:16551252] |
| 2. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.. Cell, 76 (6): (969-76). [PMID:7511063] |
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）