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CXCL12α
功能和特点
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基本描述
| 产品名称 | CXCL12α |
|---|
产品规格参数
| CAS编号和信息 | rp173767 |
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数据库链接
| Wikipedia | Stromal_cell-derived_factor-1 |
|---|---|
| UniProtKB | P48061 |
| Ensembl Gene | ENSG00000107562 |
| Entrez Gene | 6387 |
| Immunopaedia Search | CXCL12α |
| GPCRdb Ligand | CXCL12α |
关联配体
| Ligand ID | 4358 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | CXCL12α | ||||||||||
| 别名 | CXCL12 α | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
Gene deletion of CXCL12 in mice is lethal in late stage embryonic development (E18.5) |
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| 评价 | CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that mediates their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7. | ||||||||||
| 配体家族 | Chemokines | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK | ||||||||||
| 三字母多肽序列 | Lys-Pro-Val-Ser-Leu-Ser-Tyr-Arg-Cys-Pro-Cys-Arg-Phe-Phe-Glu-Ser-His-Val-Ala-Arg-Ala-Asn-Val-Lys-His-Leu-Lys-Ile-Leu-Asn-Thr-Pro-Asn-Cys-Ala-Leu-Gln-Ile-Val-Ala-Arg-Leu-Lys-Asn-Asn-Asn-Arg-Gln-Val-Cys-Ile-Asp-Pro-Lys-Leu-Lys-Trp-Ile-Gln-Glu-Tyr-Leu-Glu-Lys-Ala-Leu-Asn-Lys | ||||||||||
| 翻译后修饰 | |||||||||||
| 化学修饰 |
产品问答
产品问答
参考文献
| 1. Sierro F, Biben C, Martínez-Mu?oz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martínez-A C, Mackay CR, Mackay F. (2007) Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.. Proc Natl Acad Sci USA, 104 (37): (14759-64). [PMID:17804806] |
| 2. Patrussi L, Baldari CT. (2011) The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection.. Curr Med Chem, 18 (4): (497-512). [PMID:21143114] |
| 3. Ray P, Stacer AC, Fenner J, Cavnar SP, Meguiar K, Brown M, Luker KE, Luker GD. (2015) CXCL12-γ in primary tumors drives breast cancer metastasis.. Oncogene, 34 (16): (2043-51). [PMID:24909174] |
| 4. Wang C, Chen W, Shen J. (2018) CXCR7 Targeting and Its Major Disease Relevance.. Front Pharmacol, 9 (13): (641). [PMID:29977203] |
| 5. Nguyen HH, Kim MB, Wilson RJ, Butch CJ, Kuo KM, Miller EJ, Tahirovic YA, Jecs E, Truax VM, Wang T et al.. (2018) Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.. J Med Chem, 61 (16): (7168-7188). [PMID:30052039] |
| 6. Krikun G. (2018) The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review.. Am J Reprod Immunol, 80 (5): (e13028). [PMID:30106199] |
| 7. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T. (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.. Nature, 382 (6592): (635-8). [PMID:8757135] |
| 8. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S et al.. (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.. Nature, 393 (6685): (591-4). [PMID:9634237] |
| 9. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.. Nature, 393 (6685): (595-9). [PMID:9634238] |
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