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C5a
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基本描述
| 产品名称 | C5a |
|---|
产品规格参数
| CAS编号和信息 | rp173611 |
|---|
数据库链接
| Wikipedia | Complement_component_5a |
|---|---|
| UniProtKB | P01031 |
| Protein GI | 119607886 |
| DrugBank Target | P01031 |
| CATH/Gene3D | 1.20.91.20, 2.60.40.10 |
| Ensembl Gene | ENSG00000106804 |
靶标
| Target ID | 32 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | C5a1 receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Complement peptide receptors | ||||||||||||||||||||||||
| 别名 | 5-HT1Eβ | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| RefSeq Protein | NP_446071 (Rn) , NP_001727 (Hs) , NP_031603 (Mm) | ||||||||||||||||||||||||
| UniProtKB | P97520 (Rn) , P21730 (Hs) , P30993 (Mm) | ||||||||||||||||||||||||
| OMIM | 113995 (Hs) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_001736 (Hs) , NM_053619 (Rn) , NM_007577 (Mm) | ||||||||||||||||||||||||
| Entrez Gene | 728 (Hs) , 113959 (Rn) , 12273 (Mm) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000197405 (Hs) , ENSMUSG00000049130 (Mm) , ENSRNOG00000047800 (Rn) | ||||||||||||||||||||||||
| Protein GI | 291167769 (Mm) , 4502509 (Hs) , 16758418 (Rn) | ||||||||||||||||||||||||
| GPCRdb | c5ar1_human (Hs) , c5ar1_mouse (Mm) , c5ar1_rat (Rn) | ||||||||||||||||||||||||
| UniProtKB ID/Entry name | C5AR1_HUMAN (Hs) , C5AR1_MOUSE (Mm) , C5AR1_RAT (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL5746 (Mm) , CHEMBL2373 (Hs) , CHEMBL5770 (Rn) |
| Target ID | 33 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | C5a2 receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Complement peptide receptors | ||||||||||||||||||||||||
| 别名 | 5-HT1Eβ | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
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| RefSeq Protein | NP_001003710 (Rn) , NP_060955 (Hs) , NP_795886 (Mm) | ||||||||||||||||||||||||
| UniProtKB | Q695P6 (Rn) , Q9P296 (Hs) , Q8BW93 (Mm) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_018485 (Hs) , NM_001003710 (Rn) , NM_176912 (Mm) | ||||||||||||||||||||||||
| Entrez Gene | 27202 (Hs) , 445269 (Rn) , 319430 (Mm) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000134830 (Hs) , ENSMUSG00000074361 (Mm) , ENSRNOG00000049028 (Rn) | ||||||||||||||||||||||||
| Protein GI | 54262196 (Rn) , 225579148 (Mm) , 8923873 (Hs) | ||||||||||||||||||||||||
| OMIM | 609949 (Hs) | ||||||||||||||||||||||||
| GPCRdb | c5ar2_human (Hs) , c5ar2_mouse (Mm) , c5ar2_rat (Rn) | ||||||||||||||||||||||||
| UniProtKB ID/Entry name | C5AR2_HUMAN (Hs) , C5AR2_MOUSE (Mm) , C5AR2_RAT (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL4523478 (Hs) |
关联配体
| Ligand ID | 573 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | C5a | ||||||||||
| 别名 | human complement protein | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example). | ||||||||||
| 配体家族 | Complement components and ligands | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGR | ||||||||||
| 三字母多肽序列 | Thr-Leu-Gln-Lys-Lys-Ile-Glu-Glu-Ile-Ala-Ala-Lys-Tyr-Lys-His-Ser-Val-Val-Lys-Lys-Cys-Cys-Tyr-Asp-Gly-Ala-Cys-Val-Asn-Asn-Asp-Glu-Thr-Cys-Glu-Gln-Arg-Ala-Ala-Arg-Ile-Ser-Leu-Gly-Pro-Arg-Cys-Ile-Lys-Ala-Phe-Thr-Glu-Cys-Cys-Val-Val-Ala-Ser-Gln-Leu-Arg-Ala-Asn-Ile-Ser-His-Lys-Asp-Met-Gln-Leu-Gly-Arg | ||||||||||
| 翻译后修饰 | |||||||||||
| 化学修饰 |
参考文献
| 1. Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C et al.. (2009) C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.. Am J Respir Crit Care Med, 180 (1): (19-28). [PMID:19324972] |
| 2. Manthey HD, Woodruff TM, Taylor SM, Monk PN. (2009) Complement component 5a (C5a).. Int J Biochem Cell Biol, 41 (11): (2114-7). [PMID:19464229] |
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