产品名称 | C3a |
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CAS编号和信息 | 80295-42-7 |
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UniProtKB | P01024 |
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CATH/Gene3D | 1.20.91.20, 2.60.40.690 |
Ensembl Gene | ENSG00000125730 |
GPCRdb Ligand | C3a |
Target ID | 31 | ||||||||||||||||||||||||
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名称 | C3a receptor | ||||||||||||||||||||||||
缩写名 | SHP2 | ||||||||||||||||||||||||
家族 | Complement peptide receptors | ||||||||||||||||||||||||
别名 | 5-HT1Eβ | ||||||||||||||||||||||||
基因和蛋白信息 |
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RefSeq Protein | NP_114449 (Rn) , NP_004045 (Hs) , NP_033909 (Mm) | ||||||||||||||||||||||||
UniProtKB | O55197 (Rn) , Q16581 (Hs) , O09047 (Mm) | ||||||||||||||||||||||||
OMIM | 605246 (Hs) | ||||||||||||||||||||||||
RefSeq Nucleotide | NM_004054 (Hs) , NM_032060 (Rn) , NM_009779 (Mm) | ||||||||||||||||||||||||
Entrez Gene | 719 (Hs) , 84007 (Rn) , 12267 (Mm) | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000171860 (Hs) , ENSMUSG00000040552 (Mm) , ENSRNOG00000009211 (Rn) | ||||||||||||||||||||||||
Protein GI | 14091740 (Rn) , 4757888 (Hs) , 6753224 (Mm) | ||||||||||||||||||||||||
GPCRdb | c3ar_human (Hs) , c3ar_mouse (Mm) , c3ar_rat (Rn) | ||||||||||||||||||||||||
UniProtKB ID/Entry name | C3AR_HUMAN (Hs) , C3AR_MOUSE (Mm) , C3AR_RAT (Rn) | ||||||||||||||||||||||||
ChEMBL Target | CHEMBL4761 (Hs) |
Ligand ID | 3640 | ||||||||||
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名称 | C3a | ||||||||||
别名 | C3a anaphylatoxin polypeptide | ||||||||||
类别 | Peptide | ||||||||||
学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. | ||||||||||
配体家族 | Complement components and ligands | ||||||||||
基因/前体 |
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单字母多肽序列 | SVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLAR | ||||||||||
三字母多肽序列 | Ser-Val-Gln-Leu-Thr-Glu-Lys-Arg-Met-Asp-Lys-Val-Gly-Lys-Tyr-Pro-Lys-Glu-Leu-Arg-Lys-Cys-Cys-Glu-Asp-Gly-Met-Arg-Glu-Asn-Pro-Met-Arg-Phe-Ser-Cys-Gln-Arg-Arg-Thr-Arg-Phe-Ile-Ser-Leu-Gly-Glu-Ala-Cys-Lys-Lys-Val-Phe-Leu-Asp-Cys-Cys-Asn-Tyr-Ile-Thr-Glu-Leu-Arg-Arg-Gln-His-Ala-Arg-Ala-Ser-His-Leu-Gly-Leu-Ala-Arg | ||||||||||
翻译后修饰 | There are 3 disulfide bonds formed between the cysteine residues at positions 22 and 49, 23 and 56, 36 and 57. | ||||||||||
化学修饰 |