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β-CGRP
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基本描述
| 产品名称 | β-CGRP |
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产品规格参数
| CAS编号和信息 | rp173534 |
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数据库链接
| GPCRdb Ligand | β-CGRP |
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靶标
| Target ID | 43 | ||||||||||||||||||||||||
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| 名称 | CT receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Calcitonin receptors | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| RefSeq Protein | NP_001029187 (Rn) , NP_446268 (Rn) , NP_001733 (Hs) , NP_031614 (Mm) , NP_001158209 (Hs) | ||||||||||||||||||||||||
| UniProtKB | P32214 (Rn) , P30988 (Hs) , Q60755 (Mm) | ||||||||||||||||||||||||
| OMIM | 114131 (Hs) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_001742 (Hs) , NM_001034015 (Rn) , NM_053816 (Rn) , NM_007588 (Mm) | ||||||||||||||||||||||||
| Entrez Gene | 799 (Hs) , 116506 (Rn) , 12311 (Mm) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000004948 (Hs) , ENSMUSG00000023964 (Mm) , ENSRNOG00000010053 (Rn) | ||||||||||||||||||||||||
| Protein GI | 77404387 (Rn) , 112181179 (Mm) , 260064027 (Hs) | ||||||||||||||||||||||||
| GPCRdb | calcr_human (Hs) , calcr_mouse (Mm) , calcr_rat (Rn) | ||||||||||||||||||||||||
| UniProtKB ID/Entry name | CALCR_HUMAN (Hs) , CALCR_MOUSE (Mm) , CALCR_RAT (Rn) | ||||||||||||||||||||||||
| DrugBank Target | P30988 (Hs) | ||||||||||||||||||||||||
| CATH/Gene3D | 4.10.1240.10 (N/A) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL2204 (Rn) , CHEMBL1832 (Hs) |
| Target ID | 44 |
|---|---|
| 名称 | AMY1 receptor |
| 缩写名 | SHP2 |
| 家族 | Calcitonin receptors |
| Target ID | 46 |
|---|---|
| 名称 | AMY3 receptor |
| 缩写名 | SHP2 |
| 家族 | Calcitonin receptors |
| Target ID | 48 |
|---|---|
| 名称 | CGRP receptor |
| 缩写名 | SHP2 |
| 家族 | Calcitonin receptors |
| Target ID | 49 |
|---|---|
| 名称 | AM1 receptor |
| 缩写名 | SHP2 |
| 家族 | Calcitonin receptors |
| Target ID | 50 |
|---|---|
| 名称 | AM2 receptor |
| 缩写名 | SHP2 |
| 家族 | Calcitonin receptors |
关联配体
| Ligand ID | 682 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | β-CGRP | ||||||||||
| 别名 | β-calcitonin gene-related peptide | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. | ||||||||||
| 配体家族 | Neuropeptides | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF | ||||||||||
| 三字母多肽序列 | Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 | ||||||||||
| 翻译后修饰 | The cysteine residues at positions 2 and 7 form a disulphide bridge and the C-terminal Phenylalanine residue is amidated. | ||||||||||
| 化学修饰 |
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