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AY77

有货

库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
rp173508-500μg	500μg	期货
rp173508-1mg	1mg	期货

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PAR2 Agonist

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基本描述

产品名称	AY77

产品规格参数

CAS编号和信息	rp173508

数据库链接

GPCRdb Ligand	AY77

靶标

Target ID

348

名称

PAR2

缩写名

SHP2

家族

Proteinase-activated receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	397	2q12	F2rl1	F2R like trypsin receptor 1
Human	7	397	5q13.3	F2RL1	F2R like trypsin receptor 1
Mouse	7	399	13 49.53 cM	F2rl1	coagulation factor II (thrombin) receptor-like 1

RefSeq Protein

NP_446349 (Rn) , NP_005233 (Hs) , NP_032000 (Mm)

UniProtKB

Q63645 (Rn) , P55085 (Hs) , P55086 (Mm)

OMIM

600933 (Hs)

RefSeq Nucleotide

NM_005242 (Hs) , NM_053897 (Rn) , NM_007974 (Mm)

Entrez Gene

2150 (Hs) , 116677 (Rn) , 14063 (Mm)

Ensembl Gene

ENSG00000164251 (Hs) , ENSMUSG00000021678 (Mm) , ENSRNOG00000018003 (Rn)

Protein GI

34577052 (Hs) , 171542817 (Mm) , 16758770 (Rn)

GPCRdb

par2_human (Hs) , par2_mouse (Mm) , par2_rat (Rn)

dbSNP

rs631465 (Hs)

UniProtKB ID/Entry name

PAR2_HUMAN (Hs) , PAR2_MOUSE (Mm) , PAR2_RAT (Rn)

ChEMBL Target

CHEMBL5963 (Hs) , CHEMBL2429706 (Rn) , CHEMBL3734647 (Mm)

关联配体

Ligand ID	9455
名称	AY77
别名	compound 14 [PMID: 26819675]
类别	Peptide
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	AY77 is a potent small molecule, peptidic PAR2 agonist . The compound is stable in rat plasma making it suitable for physiological studies.
单字母多肽序列
三字母多肽序列	Isox-Cha-Chg-NH2
翻译后修饰
化学修饰	Isox= 5-isoxazole Cha= cyclohexylalanine Chg= cyclohexylglycine

参考文献

1. Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP. (2016) Potent Small Agonists of Protease Activated Receptor 2.. ACS Med Chem Lett, 7 (1): (105-10). [PMID:26819675]