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adrenomedullin
功能和特点
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基本描述
| 产品名称 | adrenomedullin |
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产品规格参数
| CAS编号和信息 | rp173386 |
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数据库链接
| CAS Registry No. | 148498-78-6 |
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| Entrez Gene | 133 |
| Wikipedia | Adrenomedullin |
关联配体
| Ligand ID | 683 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | adrenomedullin | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | Adrenomedullin is 52 amino acid peptide which is mainly expressed in endothelial and smooth muscle cells. It acts as a vasodilatory peptide and it is known to regulate endothelial barrier function and vascular tone. Evidence from animal models indicates that it is a key player in the development of sepsis-associated hemodynamic and microcirculatory disorders. | ||||||||||
| 配体家族 | Neuropeptides | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY | ||||||||||
| 三字母多肽序列 | Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 | ||||||||||
| 翻译后修饰 | The cysteine residues at positions 16 and 21 form a disulphide bridge and the C-terminal tyrosine is amidated. | ||||||||||
| 化学修饰 |
产品问答
产品问答
参考文献
| 1. Struck J, Hein F, Karasch S, Bergmann A. (2013) Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model.. Intensive Care Med Exp, 1 (1): (22). [PMID:26266791] |
| 2. Geven C, van Lier D, Blet A, Peelen R, Ten Elzen B, Mebazaa A, Kox M, Pickkers P. (2018) Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.. Br J Clin Pharmacol, 84 (9): (2129-2141). [PMID:29856470] |
| 3. Geven C, Pickkers P. (2018) The mechanism of action of the adrenomedullin-binding antibody adrecizumab.. Crit Care, 22 (1): (159). [PMID:29895302] |
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