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rifamycin SV

CAS编号: 6998-60-3
EC号: 230-273-3
PubChem编号: 6324616

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
R613189-1mg	1mg	期货
R613189-5mg	5mg	期货

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OATP1A2 Inhibitor OATP1B1 Inhibitor OATP1B3 Inhibitor OATP2B1 Inhibitor

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基本描述

英文名称	rifamycin SV
别名	Aemcolo
英文别名	Aemcolo

名称和标识符

EC号	230-273-3
IUPAC Name	[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
INCHI	InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
InChi Key	HJYYPODYNSCCOU-ODRIEIDWSA-N
Canonical SMILES	CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C
关联CAS	6998-60-3,15105-92-7 (mono-hydrochloride salt)
PubChem CID	6324616
MeSH Entry Terms	Rifamycin;Rifamycins;Rifomycin;Rifomycins

数据库链接

CAS Registry No.	6998-60-3
PubChem CID	6324616
ChEMBL Ligand	CHEMBL437765
ChEBI	CHEBI:29673
DrugCentral Ligand	4817
Antibiotic DB	1860

关联配体

Ligand ID	4570
名称	rifamycin SV
别名	Aemcolo®
类别	Natural product
学名	(7S,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	One of the Ansamycin group of antibacterials. Rifamycin is a natural antibacterial that is produced by Streptomyces mediterranei that exhibits antibacterial and antitubercular properties. Rifamycins are particularly effective against mycobacteria, and are most commonly used to treat tuberculosis, leprosy, and mycobacterium avium complex (MAC) infections.

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参考文献

1. DuPont HL, Petersen A, Zhao J, Mundt A, Jiang ZD, Miller S, Flores J, Shringarpure R, Moro L, Bagin RG et al.. (2014) Targeting of rifamycin SV to the colon for treatment of travelers' diarrhea: a randomized, double-blind, placebo-controlled phase 3 study.. J Travel Med, 21 (6): (369-76). [PMID:25345982]
2. Lin SW, Lin CJ, Yang JC. (2017) Rifamycin SV MMX for the treatment of traveler's diarrhea.. Expert Opin Pharmacother, 18 (12): (1269-1277). [PMID:28697313]

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