91高清自产国产拍,无码免费A级毛片大全,日本欧美国产中文字幕,99re热视频这里只有精品视频首页

400-620-6333

提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.

语言

切换导航

我的购物车

搜索

语言

首页
应用
药物靶标
激酶
AGC：包含PKA，PKG，PKC家族
(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide

(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide

PubChem编号: 155749520

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
R608974-5mg	5mg	期货
R608974-25mg	25mg	期货

查看相关系列

protein kinase C delta Inhibitor Rho associated coiled-coil containing protein kinase 2 Inhibitor ribosomal protein S6 kinase A4 Inhibitor ribosomal protein S6 kinase A5 Inhibitor

Skip to the end of the images gallery

main product photo

Skip to the beginning of the images gallery

基本描述

英文名称	(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide
别名	compound 23
英文别名	compound 23

名称和标识符

IUPAC Name	(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide
INCHI	InChI=1S/C20H25FN4O2/c1-14-13-24(19-7-8-22-12-18(19)21)9-10-25(14)20(26)23-15(2)16-5-4-6-17(11-16)27-3/h4-8,11-12,14-15H,9-10,13H2,1-3H3,(H,23,26)/t14-,15-/m1/s1
InChi Key	CIPXFTLGPVQJKN-HUUCEWRRSA-N
Canonical SMILES	Fc1cnccc1N1C[C@H](N(CC1)C(=O)N[C@H](C)c1cc(ccc1)OC)C
PubChem CID	155749520

数据库链接

PubChem CID	155749520

关联配体

Ligand ID	12059
名称	compound 23 [PMID: 35816678]
类别	Synthetic organic
学名	(2R)-4-(3-fluoropyridin-4-yl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methylpiperazine-1-carboxamide
生物活性评价	LIMK2 (IC₅₀ 25 nM) is a likely off-target of compound 23. LIMK2's role in the ROCK-Cofilin pathway suggest that this secondary interaction may influence its apparent potency in cell assays.
评价	This small molecule is a potent Rho kinase (ROCK) inhibitor . It was designed to be selective and to cross the blood-brain barrier, in order to evaluate the potential of ROCK inhibition as a disease modifier in Huntington's disease, since ROCK has been implicated in mutant huntingtin protein's aggregation and neurotoxic effects.

相关文档

质检报告COA

请输入批号:

SDS中文版 SDS英文版

质量技术规格说明书

产品问答

产品问答

登录提交问题

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Ladduwahetty T, Lee MR, Maillard MC, Cachope R, Todd D, Barnes M, Beaumont V, Chauhan A, Gallati C, Haughan AF et al.. (2022) Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.. J Med Chem, 71 (13): (1755-70). [PMID:35816678]

上海阿拉丁生化科技股份有限公司

销售条款及条件 ? ? ? ? 隐私政策

? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

沪公网安备 31012002004058号沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

危险品化学品经营许可证（带存储）

营业执照(三证合一)