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利托那韦

HIV-1和HIV-2蛋白酶抑制剂
规格或纯度: ≥98%
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R126586-10mg 10mg 现货 Stock Image
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CYP3A4 Inhibitor CYP3A5 Inhibitor UDP glucuronosyltransferase family 1 member A1 Inhibitor
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基本描述

规格或纯度 ≥98%
英文名称 Ritonavir
别名 利托那韦；N-[(2S,3S,5S)-3-羟基-5-[[(2S)-3-甲基-2-[[甲基-[(2-异丙基-1,3-噻唑-4-基)甲基]氨基甲酰]氨基]丁酰]氨基]-1,6-二苯基-己-2-基]氨基甲酸 5-噻唑基甲基酯
英文别名 A 84538; ABT 538; Abbott 84538; NSC 693184; Norvir; RTV;Thiazol-5-ylmethyl [(1S,2S,4S)-1-benzyl-2-hydroxy-4- [[(2S)-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol- 4-yl]methyl]carbamoyl]amino]butanoyl]amino]-5- phenylpentyl]carbamate；ABT-538；A-84538；1,3-th
生化机理 HIV-1和HIV-2蛋白酶抑制剂（EC50值分别为0.022-0.13和0.16μM）。通过肝酶细胞色素P450-3A4（CYP3A4）阻止蛋白酶抑制剂的代谢。口服具有生物活性。当与洛匹那韦联合使用时，可改善MERS-CoV感染动物模型的预后。
储存温度 2-8°C储存
运输条件 冰袋运输
备注 卖完停产，不再备货
产品介绍

Ritonavir是一种HIV蛋白酶抑制剂，用于治疗HIV感染和AIDS。


产品介绍：

Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂，IC50 为 1.61 μM。

Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).


Application：

Ritonavir has been used:

as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function

as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells

as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin

名称和标识符

IUPAC Name 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
INCHI InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChi Key NCDNCNXCDXHOMX-XGKFQTDJSA-N
Canonical SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
分子式

C37H48N6O5S2
PubChem CID 392622
分子量 720.94

化学和物理性质

溶解性 溶于DMSO, 最高浓度 (mg/mL): 14.42, 最高浓度(mM): 20 温和加热；溶于ethanol, 最高浓度 (mg/mL): 7.21, 最高浓度(mM): 10

安全信息

象形图
ghs08

Health Hazard

ghs07

Harmful
信号词 Warning
危险声明 H319: Causes serious eye irritation
H351: Suspected of causing cancer
H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
H302+H312+H332: Harmful if swallowed, in contact with skin or if inhaled
H361: Suspected of damaging fertility or the unborn child
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P362+P364,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317
WGK Germany 3
RTECS XA5310000

靶标

Target ID 1337
名称 CYP3A4
缩写名 SHP2
家族 CYP3 family
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 1 503 7q22.1 CYP3A4 cytochrome P450 family 3 subfamily A member 4
Ensembl Gene ENSG00000160868 (Hs)
Entrez Gene 1576 (Hs)
OMIM 124010 (Hs)
Protein GI 322302351 (Hs)
UniProtKB P08684 (Hs)
ChEMBL Target CHEMBL340 (Hs)
Target ID 1338
名称 CYP3A5
缩写名 SHP2
家族 CYP3 family
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 2 502 7q22.1 CYP3A5 cytochrome P450 family 3 subfamily A member 5
Ensembl Gene ENSG00000106258 (Hs)
Entrez Gene 1577 (Hs)
OMIM 605325 (Hs)
Protein GI 306518609 (Hs)
UniProtKB P20815 (Hs)
ChEMBL Target CHEMBL3019 (Hs)
Target ID 2990
名称 UDP glucuronosyltransferase family 1 member A1
缩写名 SHP2
家族 UDP glucuronosyltransferases (UGT)
别名 CNG1
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 1 533 2q37.1 UGT1A1 UDP glucuronosyltransferase family 1 member A1
Mouse 1 535 1 44.55 cM Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1
Rat 1 535 9q35 Ugt1a1 UDP glucuronosyltransferase family 1 member A1
Entrez Gene 54658 (Hs) , 394436 (Mm) , 24861 (Rn)
UniProtKB P22309 (Hs) , Q63886 (Mm) , Q64550 (Rn)
Ensembl Gene ENSG00000241635 (Hs) , ENSMUSG00000089960 (Mm) , ENSRNOG00000018740 (Rn)
OMIM 191740 (Hs)
RefSeq Protein NP_036815 (Rn) , NP_000454 (Hs) , NP_964007 (Mm)
Protein GI 136729 (Hs) , 342187101 (Mm) , 2501473 (Rn)
ChEMBL Target CHEMBL1287617 (Hs) , CHEMBL4523337 (Mm) , CHEMBL4523339 (Rn)

关联配体

Ligand ID 8804
名称 ritonavir
别名 ABT-538
类别 Synthetic organic
学名 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-di(phenyl)hexan-2-yl]carbamate
生物活性评价 Inhibition of CYP3A4 by ritonavir blocks this metabolizing enzyme form breaking down other antiviral protease inhibitors, and in so-doing enhances the activity of the other protease inhibitors it is administered with. This activity means that potentially dangerous pharmacokinetic interactions are likely if ritonavir is administered with other drugs that are inhibitors of CYP3A (and also of CYP2D6) e.g. alfuzosin, amiodarone, cisapride, ergot alkaloids, flecainide, lovastatin, oral midazolam, pimozide, propafenone, quinidine, sildenafil, simvastatin and triazolam. St. John's wort is a CYP3A inducer that can decrease substrate drug levels to sub-therapeutic concentrations.
评价 Ritonavir is an orally bioavailable antiviral that is generally administered in combination with other anti-HIV or anti-HCV drugs.

参考文献

1. Zeldin RK, Petruschke RA.  (2004)  Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients..  J Antimicrob Chemother,  53  (1):  (4-9).  [PMID:14657084]

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