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规格或纯度: for fluorescence,≥98.0%

CAS编号: 130-95-0
分子式: C₂₀H₂₄N₂O₂
分子量: 324.42
Beilstein号: 91867
EC号: 205-003-2
MDL号: MFCD00198096
PubChem编号: 3034034

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货号 (SKU)	包装规格	是否现货
Q105030-1g	1g	现货
Q105030-5g	5g	现货
Q105030-25g	25g	现货
Q105030-100g	100g	现货

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K2P18.1 Channel blocker Kv2.2 Channel blocker Plasma membrane monoamine transporter Inhibitor Plasmodium falciparum purine nucleoside phosphorylase Inhibitor TAS2R14 Agonist TAS2R40 Agonist VRAC Channel blocker

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基本描述

规格或纯度	for fluorescence,≥98.0%
英文名称	Quinine
别名	金鸡纳碱
生化机理	钾通道阻断剂。
储存温度	避光,充氩
运输条件	常规运输
产品介绍	Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.钾离子通道阻断剂。手性催化剂，用于高异构体选择性[2+2]环加成反应；二乙基锌添加到醛上。 Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.

名称和标识符

EC号	205-003-2
IUPAC Name	(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
INCHI	InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
InChi Key	LOUPRKONTZGTKE-WZBLMQSHSA-N
Canonical SMILES	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
分子式	C₂₀H₂₄N₂O₂
PubChem CID	3034034
Beilstein号	91867
分子量	324.42

数据库链接

PubChem CID	3034034
DrugBank Ligand	DB00468
CAS Registry No.	130-95-0
ChEBI	CHEBI:15854
Wikipedia	Quinine
BitterDB Ligand	38
ChEMBL Ligand	CHEMBL170
RCSB PDB Ligand	QI9
DrugCentral Ligand	4523

化学和物理性质

溶解性	Soluble in alcohol, chloroform and diethyl ether. Slightly soluble in water and glycerol.
密度	1.21
敏感性	对光线、湿度敏感
熔点	173-177°C

安全信息

象形图	Health Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H302: Harmful if swallowed H317: May cause an allergic skin reaction H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P501,P264,P284,P270,P304+P340,P272,P333+P313,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P342+P316
WGK Germany	3
RTECS	VA6020000
Reaxy-Rn	5293630
Merck Index	8061
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

靶标

Target ID

527

名称

K_2P18.1

缩写名

TRESK

家族

Two-pore domain potassium channels (K_2P)

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	4	384	10q25.3	KCNK18	potassium two pore domain channel subfamily K member 18
Rat	4	405	1q55	Kcnk18	potassium two pore domain channel subfamily K member 18
Mouse	4	394	19 D3	Kcnk18	potassium channel, subfamily K, member 18

Entrez Gene

445371 (Rn) , 332396 (Mm) , 338567 (Hs)

UniProtKB

Q6Q1P3 (Rn) , Q7Z418 (Hs) , Q6VV64 (Mm)

RefSeq Protein

NP_862823 (Hs) , NP_001003820 (Rn) , NP_997144 (Mm)

RefSeq Nucleotide

NM_181840 (Hs) , NM_001003820 (Rn) , NM_207261 (Mm)

Ensembl Gene

ENSG00000186795 (Hs) , ENSMUSG00000040901 (Mm) , ENSRNOG00000032706 (Rn)

Protein GI

46402279 (Mm) , 32469495 (Hs) , 201023277 (Rn)

OMIM

613655 (Hs)

ChEMBL Target

CHEMBL2331042 (Hs)

Target ID

547

名称

K_v2.2

缩写名

SHP2

家族

Voltage-gated potassium channels (K_v)

别名

CC CK₄

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	911	8q21.11	KCNB2	potassium voltage-gated channel subfamily B member 2
Rat	6	907	5q11	Kcnb2	potassium voltage-gated channel subfamily B member 2
Mouse	6	907	1 4.5 cM	Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2

OMIM

607738 (Hs)

Entrez Gene

117105 (Rn) , 98741 (Mm) , 9312 (Hs)

UniProtKB

Q63099 (Rn) , A6H8H5 (Mm) , Q92953 (Hs)

RefSeq Protein

NP_004761 (Hs) , NP_446452 (Rn) , NP_001091998 (Mm)

RefSeq Nucleotide

NM_004770 (Hs) , NM_054000 (Rn) , NM_001098528 (Mm)

Ensembl Gene

ENSG00000182674 (Hs) , ENSMUSG00000092083 (Mm) , ENSRNOG00000028991 (Rn)

Protein GI

27436974 (Hs) , 148664234 (Mm) , 164663795 (Rn)

DrugBank Target

Q92953 (Hs)

ChEMBL Target

CHEMBL2321618 (Hs)

Target ID

668

名称

TAS2R14

缩写名

SHP2

家族

Taste 2 receptors

别名

LESTR

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	7	317	12p13.2	TAS2R14	taste 2 receptor member 14

Entrez Gene

50840 (Hs)

OMIM

604790 (Hs)

UniProtKB

Q9NYV8 (Hs)

Ensembl Gene

ENSG00000212127 (Hs)

RefSeq Nucleotide

NM_023922 (Hs)

Protein GI

12965182 (Hs)

GPCRdb

t2r14_human (Hs)

BitterDB Receptor

14 (Hs)

UniProtKB ID/Entry name

T2R14_HUMAN (Hs)

ChEMBL Target

CHEMBL3309105 (Hs)

Target ID

676

名称

TAS2R40

缩写名

SHP2

家族

Taste 2 receptors

别名

LESTR

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	7	323	7q34	TAS2R40	taste 2 receptor member 40

Entrez Gene

259286 (Hs)

OMIM

613964 (Hs)

UniProtKB

P59535 (Hs)

Ensembl Gene

ENSG00000221937 (Hs)

RefSeq Nucleotide

NM_176882 (Hs)

Protein GI

28882033 (Hs)

GPCRdb

t2r40_human (Hs)

BitterDB Receptor

40 (Hs)

UniProtKB ID/Entry name

T2R40_HUMAN (Hs)

ChEMBL Target

CHEMBL4523250 (Hs)

Target ID	710
名称	VRAC
缩写名	SHP2
家族	Volume regulated chloride channels (VRAC)
别名	CCK-B

Target ID

1120

名称

Plasma membrane monoamine transporter

缩写名

PMAT

家族

SLC29 family

别名

GPR-chr2

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	10	530	7p22.1	SLC29A4	solute carrier family 29 member 4
Mouse	10	528	5 G2	Slc29a4	solute carrier family 29 (nucleoside transporters), member 4
Rat	2	147	18p11	Slc29a4	solute carrier family 29 member 4

Ensembl Gene

ENSG00000164638 (Hs) , ENSMUSG00000050822 (Mm) , ENSRNOG00000001115 (Rn)

Entrez Gene

243328 (Mm) , 288499 (Rn) , 222962 (Hs)

OMIM

609149 (Hs)

Protein GI

157787066 (Rn) , 22122849 (Mm) , 100913034 (Hs)

UniProtKB

Q7RTT9 (Hs) , Q8R139 (Mm)

Bioparadigms SLC Tables

SLC29A4 (Hs)

RESOLUTE

SLC29A4 (Hs)

ChEMBL Target

CHEMBL3509593 (Hs)

Target ID

3077

名称

Plasmodium falciparum purine nucleoside phosphorylase

缩写名

PfPNP

家族

Nucleoside synthesis and metabolism (Plasmodium spp.)

别名

Kir4.1

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Plasmodium falciparum 3D7	2	245	18p11	PNP	purine nucleoside phosphorylase

UniProtKB

Q8I3X4 (Pf3D7)

PlasmoDB

PF3D7_0513300 (Pf3D7)

ChEMBL Target

CHEMBL4523389 (Pf3D7)

关联配体

Ligand ID	2510
名称	quinine
别名	Qualaquin®
类别	Natural product
学名	(R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	First extracted from the bark of the cinchona tree and used as an antimalarial medicine, quinine has also been synthesized in the laboratory . The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
配体家族	Antimalarial ligands

参考文献

1. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. (2011) Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria.. Malar J, 10 (13): (144). [PMID:21609473]

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奎宁

库存信息

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库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全信息

靶标

关联配体

参考文献

相关文档

质检报告COA

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91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

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