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普罗瑞林

THR 活化剂

规格或纯度: 95%

CAS编号: 24305-27-9
分子式: C₁₆H₂₂N₆O₄
分子量: 362.38
Beilstein号: 770238
EC号: 246-143-4
PubChem编号: 638678

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货号 (SKU)	包装规格	是否现货
P413167-10mg	10mg	现货
P413167-50mg	50mg	现货
P413167-100mg	100mg	现货

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TRH1 receptor Agonist TRH2 receptor Agonist

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基本描述

规格或纯度	95%
英文名称	Protirelin
英文别名	Thyroliberin;Lopremone;Synthetic TRH;Thyrotropin-releasing hormone;RifathyroinL-?Prolinamide,5-?oxo-?L-?prolyl-?L-?histidyl-
生化机理	Protirelin (Thyroliberin, Lopremone, Synthetic TRH, Thyrotropin-releasing hormone, Rifathyroin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information Protirelin Protirelin (Thyroliberin, Lopremone, Synthetic TRH, Thyrotropin-releasing hormone, Rifathyroin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

名称和标识符

EC号	246-143-4
IUPAC Name	(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
INCHI	InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChi Key	XNSAINXGIQZQOO-SRVKXCTJSA-N
Canonical SMILES	C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N
RTECS	TW3580000
PubChem CID	638678
分子量	362.38
Beilstein号	770238

数据库链接

PubChem CID	638678
UniProtKB	P20396, P01150, Q62361
Wikipedia	Thyrotropin-releasing_hormone
ChEMBL Ligand	CHEMBL1472
CAS Registry No.	24305-27-9
PEP	trh
DrugCentral Ligand	2316
Ensembl Gene	ENSG00000170893, ENSMUSG00000005892, ENSRNOG00000011824
GPCRdb Ligand	TRH

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 72 mg/mL (198.68 mM); Water: 72 mg/mL (198.68 mM); Ethanol: 72 mg/mL (198.68 mM);
折光率	n20D1.62 (Predicted)
沸点	~978.4° C at 760 mmHg (Predicted)

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H332: Harmful if inhaled
预防措施声明	P261,P271,P304+P340,P317
RTECS	TW3580000

关联配体

Ligand ID

2139

名称

TRH

别名

thyroliberin

类别

Peptide

学名

(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH.

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
TRH	thyrotropin releasing hormone	thyrotropin-releasing hormone (Prothyroliberin)	Human	thyrotropin-releasing hormone
Trh	thyrotropin releasing hormone	thyrotropin-releasing hormone (Prothyroliberin)	Rat	THR, TRH01, Thyrotropin releasing hormone, Tryrotropin releasing hormone, prothyroliberin, thyrotropin-releasing hormone

单字母多肽序列

XHP

三字母多肽序列

pGlu-His-Pro-NH2

翻译后修饰

N-terminal pyroglutamate (X or pGlu) and C terminal amidation.

化学修饰

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参考文献

1. Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.. Life Sci, 72 (4-5): (601-7). [PMID:12467901]