| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P412000-1mg | 1mg |
现货  |
| |
| P412000-5mg | 5mg |
现货 |
| |
| P412000-10mg | 10mg |
期货 |
|
| 产品名称 | Pertuzumab (anti-HER2) |
|---|---|
| 规格或纯度 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 特异性 | ERBB2/HER2/CD340 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 反应种属 | Human,Mouse?,Rat? |
| 偶联标记 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | Kappa |
| SDS-PAGE | 145.44 kDa |
| 纯化方法 | Protein A purified |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | Lot by Lot |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 380610-27-5 |
| Wikipedia | Pertuzumab |
|---|---|
| IMGT/mAb-DB | 80 |
| PubChem SID | 178101741 |
| Reactome Reaction | R-HSA-9665726, R-HSA-9665703, R-HSA-9665708 |
| Reactome Drug | R-ALL-9665971 |
| Target ID | 2019 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | erb-b2 receptor tyrosine kinase 2 | ||||||||||||||||||||||||
| 缩写名 | HER2 | ||||||||||||||||||||||||
| 家族 | Type I RTKs: ErbB (epidermal growth factor) receptor family | ||||||||||||||||||||||||
| 别名 | MAS-related GPR, member G | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| Ensembl Gene | ENSG00000141736 (Hs) , ENSMUSG00000062312 (Mm) , ENSRNOG00000006450 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 2064 (Hs) , 13866 (Mm) , 24337 (Rn) | ||||||||||||||||||||||||
| OMIM | 164870 (Hs) | ||||||||||||||||||||||||
| UniProtKB | P04626 (Hs) , P06494 (Rn) , P70424 (Mm) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_001005862 (Hs) , NM_010194 (Mm) , NM_017003 (Rn) | ||||||||||||||||||||||||
| RefSeq Protein | NP_001005862 (Hs) , NP_034324 (Mm) , NP_058699 (Rn) | ||||||||||||||||||||||||
| Protein GI | 111185914 (Mm) , 77020289 (Rn) , 54792098 (Hs) | ||||||||||||||||||||||||
| DrugBank Target | P04626 (Hs) | ||||||||||||||||||||||||
| CATH/Gene3D | 3.80.20.20 (N/A) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3848 (Rn) , CHEMBL2311234 (Mm) , CHEMBL1824 (Hs) |
| Ligand ID | 5046 |
|---|---|
| 名称 | pertuzumab |
| 别名 | Omnitarg® (obsolete trade name) |
| 类别 | Antibody |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Annotated peptide sequences for this antibody are available in its IMGT/mAB-DB record. |
| 单字母多肽序列 | |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
| 1. Badache A, Hynes NE. (2004) A new therapeutic antibody masks ErbB2 to its partners.. Cancer Cell, 5 (4): (299-301). [PMID:15093533] |
| 2. Ferguson KM. (2004) Active and inactive conformations of the epidermal growth factor receptor.. Biochem Soc Trans, 32 (Pt 5): (742-5). [PMID:15494003] |
| 3. Adams CW, Allison DE, Flagella K, Presta L, Clarke J, Dybdal N, McKeever K, Sliwkowski MX. (2006) Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab.. Cancer Immunol Immunother, 55 (6): (717-27). [PMID:16151804] |
| 4. Harbeck N, Beckmann MW, Rody A, Schneeweiss A, Müller V, Fehm T, Marschner N, Gluz O, Schrader I, Heinrich G et al.. (2013) HER2 Dimerization Inhibitor Pertuzumab - Mode of Action and Clinical Data in Breast Cancer.. Breast Care (Basel), 8 (1): (49-55). [PMID:24715843] |
Pertuzumab (anti-HER2) (P412000) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Pertuzumab (anti-HER2) (P412000). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Pertuzumab (anti-HER2) (P412000) - SEC
The purity of Pertuzumab (anti-HER2) (P412000) is more than 95% verified by HPLC.
首页
400-620-6333
危险品化学品经营许可证（带存储）