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帕唑帕尼

规格或纯度: ≥99%

CAS编号: 444731-52-6
分子式: C₂₁H₂₃N₇O₂S
分子量: 437.53
PubChem编号: 10113978

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货号 (SKU)	包装规格	是否现货	价格	数量
P125184-25mg	25mg	现货
P125184-100mg	100mg	现货
P125184-500mg	500mg	现货
P125184-1g	1g	现货
P125184-5g	5g	现货
P125184-25g	25g	现货

查看相关系列

colony stimulating factor 1 receptor Inhibitor fibroblast growth factor receptor 1 Inhibitor fms related receptor tyrosine kinase 1 Inhibitor fms related receptor tyrosine kinase 4 Inhibitor kinase insert domain receptor Inhibitor KIT proto-oncogene，receptor tyrosine kinase Inhibitor platelet derived growth factor receptor beta Inhibitor

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基本描述

规格或纯度	≥99%
英文名称	Pazopanib
别名	VEGFR抑制剂\|帕唑帕尼
英文别名	Pazopanib\|444731-52-6\|GW786034\|pazopanibum\|5-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide\|GW 786034\|UNII-7RN5DR86CK\|7RN5DR86CK\|NSC-752782\|790713-33-6\|DTXSID8048733\|GW 78603\|CHEBI:71219\|indazolylpyrimidi
生化机理	Pazopanib is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which are key proteins responsible for tumor growth and angiogenesis.A potent and selective inhibitor of Flk-1, PDGFR and c-kit Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which are key proteins responsible for tumor growth and angiogenesis. A potent and selective inhibitor of Flk-1, PDGFR and c-kit

名称和标识符

IUPAC Name	5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
INCHI	InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChi Key	CUIHSIWYWATEQL-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
PubChem CID	10113978
分子量	437.53

数据库链接

CAS Registry No.	444731-52-6
Wikipedia	Pazopanib
DiscoveRx TREEspot	Pazopanib\|
PubChem CID	10113978
ChEMBL Ligand	CHEMBL477772
PEP	pazopanib
Reactome Reaction	R-HSA-9674427, R-HSA-9674093, R-HSA-2077424, R-HSA-9693978, R-HSA-2029992
Reactome Drug	R-ALL-9616920
DrugCentral Ligand	4118

化学和物理性质

溶解性	DMSO 88 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

关联配体

Ligand ID	5698
名称	pazopanib
别名	GW 786034
类别	Synthetic organic
学名	5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Pazopanib is a Type-1 kinase inhibitor. Its discovery is reported in . It targets multiple receptor tyrosine kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRβ, FGFR1, Kit and CSF1R).

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参考文献

1. Harris PA, Cheung M, Hunter 3rd RN, Brown ML, Veal JM, Nolte RT, Wang L, Liu W, Crosby RM, Johnson JH et al.. (2005) Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.. J Med Chem, 48 (5): (1610-9). [PMID:15743202]
2. Harris PA, Boloor A, Cheung M, Kumar R, Crosby RM, Davis-Ward RG, Epperly AH, Hinkle KW, Hunter 3rd RN, Johnson JH et al.. (2008) Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.. J Med Chem, 51 (15): (4632-40). [PMID:18620382]

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