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肽 YY 片段 3-36 人

规格或纯度: ≥95% (HPLC),冻干粉
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货号 (SKU) 包装规格 是否现货 价格 数量
P118904-0.5mg 0.5mg 现货 Stock Image
P118904-1mg 1mg 现货 Stock Image
P118904-5mg 5mg 现货 Stock Image
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Y1 receptor Agonist Y2 receptor Agonist Y4 receptor Agonist
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基本描述

规格或纯度 ≥95% (HPLC),冻干粉
英文名称 Peptide YY Fragment 3-36 human
别名 Peptide YY(3-36), PYY, human
英文别名 Peptide YY(3-36), PYY, human
生化机理 Y2/Y5神经肽Y受体激动剂。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

氨基酸序列 Ile-Lys-Pro-Glu-Ala-Pro-G?ly-Glu-Asp-Ala-Ser-Pro-Gl?u-Glu-Leu-Asn-Arg-Tyr-Tyr?-Ala-Ser-Leu-Arg-His-Tyr-?Leu-Asn-Leu-Val-Thr-Arg-G?ln-Arg-Tyr-NH2

Amino Acid Sequence Ile-Lys-Pro-Glu-Ala-Pro-G?ly-Glu-Asp-Ala-Ser-Pro-Gl?u-Glu-Leu-Asn-Arg-Tyr-Tyr?-Ala-Ser-Leu-Arg-His-Tyr-?Leu-Asn-Leu-Val-Thr-Arg-G?ln-Arg-Tyr-NH2

名称和标识符

IUPAC Name (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoic acid
INCHI InChI=1S/C176H272N52O54/c1-84(2)67-114(155(265)202-104(27-19-61-192-174(184)185)148(258)218-121(75-98-78-190-83-196-98)160(270)217-120(74-97-39-47-102(236)48-40-97)158(268)212-115(68-85(3)4)156(266)219-122(76-131(180)238)161(271)213-117(70-87(7)8)162(272)224-138(88(9)10)168(278)225-139(93(15)232)169(279)208-106(29-21-63-194-176(188)189)145(255)204-108(49-54-130(179)237)150(260)201-103(26-18-60-191-173(182)183)146(256)210-113(140(181)250)71-94-33-41-99(233)42-34-94)214-164(274)124(80-229)221-142(252)90(12)197-153(263)118(72-95-35-43-100(234)44-36-95)216-159(269)119(73-96-37-45-101(235)46-38-96)215-147(257)105(28-20-62-193-175(186)187)203-163(273)125(81-230)222-157(267)116(69-86(5)6)211-152(262)110(52-57-135(244)245)205-151(261)111(53-58-136(246)247)207-167(277)129-32-24-66-228(129)172(282)126(82-231)223-143(253)91(13)198-154(264)123(77-137(248)249)220-149(259)107(50-55-133(240)241)200-132(239)79-195-165(275)127-30-22-64-226(127)170(280)92(14)199-144(254)109(51-56-134(242)243)206-166(276)128-31-23-65-227(128)171(281)112(25-16-17-59-177)209-141(251)89(11)178/h33-48,78,83-93,103-129,138-139,229-236H,16-32,49-77,79-82,177-178H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,250)(H,190,196)(H,195,275)(H,197,263)(H,198,264)(H,199,254)(H,200,239)(H,201,260)(H,202,265)(H,203,273)(H,204,255)(H,205,261)(H,206,276)(H,207,277)(H,208,279)(H,209,251)(H,210,256)(H,211,262)(H,212,268)(H,213,271)(H,214,274)(H,215,257)(H,216,269)(H,217,270)(H,218,258)(H,219,266)(H,220,259)(H,221,252)(H,222,267)(H,223,253)(H,224,272)(H,225,278)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H4,182,183,191)(H4,184,185,192)(H4,186,187,193)(H4,188,189,194)/t89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,138-,139-/m0/s1
InChi Key AIYOBVCUSVSXOL-NYGOYQSZSA-N
Canonical SMILES CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C6CCCN6C(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(C)N
分子式

C180H279N53O54
PubChem CID 90479816
分子量 4049.55

靶标

Target ID 305
名称 Y1 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 382 16p14 Npy1r neuropeptide Y receptor Y1
Human 7 384 4q32.2 NPY1R neuropeptide Y receptor Y1
Mouse 7 382 8 33.15 cM Npy1r neuropeptide Y receptor Y1
RefSeq Protein NP_001106828 (Rn) , NP_000900 (Hs) , NP_035064 (Mm)
UniProtKB P21555 (Rn) , P25929 (Hs) , Q04573 (Mm)
OMIM 162641 (Hs)
RefSeq Nucleotide NM_000909 (Hs) , NM_001113357 (Rn) , NM_010934 (Mm)
Entrez Gene 4886 (Hs) , 29358 (Rn) , 18166 (Mm)
Ensembl Gene ENSG00000164128 (Hs) , ENSMUSG00000036437 (Mm) , ENSRNOG00000014149 (Rn)
Protein GI 4505445 (Hs) , 6754882 (Mm) , 164518921 (Rn)
GPCRdb npy1r_human (Hs) , npy1r_mouse (Mm) , npy1r_rat (Rn)
UniProtKB ID/Entry name NPY1R_HUMAN (Hs) , NPY1R_MOUSE (Mm) , NPY1R_RAT (Rn)
ChEMBL Target CHEMBL4739851 (Mm) , CHEMBL4777 (Hs) , CHEMBL2587 (Rn)
Target ID 306
名称 Y2 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 381 2q34 Npy2r neuropeptide Y receptor Y2
Human 7 381 4q32.1 NPY2R neuropeptide Y receptor Y2
Mouse 7 381 3 36.49 cM Npy2r neuropeptide Y receptor Y2
RefSeq Protein NP_076458 (Rn) , NP_000901 (Hs) , NP_032757 (Mm)
UniProtKB Q9ERC0 (Rn) , P49146 (Hs) , P97295 (Mm)
OMIM 162642 (Hs)
RefSeq Nucleotide NM_000910 (Hs) , NM_023968 (Rn) , NM_008731 (Mm)
Entrez Gene 4887 (Hs) , 66024 (Rn) , 18167 (Mm)
Ensembl Gene ENSG00000185149 (Hs) , ENSMUSG00000028004 (Mm) , ENSRNOG00000049213 (Rn)
Protein GI 13027422 (Rn) , 4505447 (Hs) , 326633237 (Mm)
GPCRdb npy2r_human (Hs) , npy2r_mouse (Mm) , q9erc0_rat (Rn)
UniProtKB ID/Entry name NPY2R_HUMAN (Hs) , NPY2R_MOUSE (Mm) , Q9ERC0_RAT (Rn)
ChEMBL Target CHEMBL3309 (Rn) , CHEMBL4018 (Hs) , CHEMBL4739850 (Mm)
Target ID 307
名称 Y4 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 375 16p15 Npy4r neuropeptide Y receptor Y4
Human 7 375 10q11.22 NPY4R neuropeptide Y receptor Y4
Mouse 7 375 14 20.8 cM Npy4r neuropeptide Y receptor Y4
RefSeq Protein NP_113769 (Rn) , NP_005963 (Hs) , NP_032945 (Mm)
UniProtKB Q63447 (Rn) , P50391 (Hs) , Q61041 (Mm)
OMIM 601790 (Hs)
RefSeq Nucleotide NM_005972 (Hs) , NM_031581 (Rn) , NM_008919 (Mm)
Entrez Gene 5540 (Hs) , 29471 (Rn) , 19065 (Mm)
Ensembl Gene ENSG00000204174 (Hs) , ENSMUSG00000048337 (Mm) , ENSRNOG00000061026 (Rn)
Protein GI 13928788 (Rn) , 157364957 (Hs) , 157057097 (Mm)
GPCRdb npy4r_human (Hs) , npy4r_mouse (Mm) , npy4r_rat (Rn)
UniProtKB ID/Entry name NPY4R_HUMAN (Hs) , NPY4R_MOUSE (Mm) , NPY4R_RAT (Rn)
ChEMBL Target CHEMBL4877 (Hs) , CHEMBL4827 (Rn) , CHEMBL4105736 (Mm)

关联配体

Ligand ID 1517
名称 PYY-(3-36)
别名 human peptide YY (3-36)
类别 Peptide
学名 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.
配体家族 Neuropeptides
基因/前体
Gene symbol Gene name Precursor protein name Species 别名
PYY peptide YY prepro-PYY Human PYY1
单字母多肽序列 IKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY
三字母多肽序列 Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
翻译后修饰 The C-terminal tyrosine is amidated.
化学修饰

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