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基本描述
| 英文名称 | NS6740 |
|---|---|
| 别名 | A-793394;A793394;NS-6740 |
| 英文别名 | A-793394;A793394;NS-6740 |
名称和标识符
| IUPAC Name | 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methanone |
|---|---|
| INCHI | InChI=1S/C19H19F3N2O2/c20-19(21,22)14-3-1-2-13(12-14)16-4-5-17(26-16)18(25)24-11-10-23-8-6-15(24)7-9-23/h1-5,12,15H,6-11H2 |
| InChi Key | VSOWCIMCDKXVRC-UHFFFAOYSA-N |
| Canonical SMILES | O=C(N1CCN2CCC1CC2)c1ccc(o1)c1cccc(c1)C(F)(F)F |
| PubChem CID | 10021664 |
数据库链接
| PubChem CID | 10021664 |
|---|---|
| ChEMBL Ligand | CHEMBL2380804 |
关联配体
| Ligand ID | 11383 |
|---|---|
| 名称 | NS6740 |
| 别名 | A-793394 |
| 类别 | Synthetic organic |
| 学名 | 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methanone |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
NS6740 (A-582941) is described as a silent agonist (or metagonist) of α7 nicotinic acetylcholine receptors (CHRNA7; nAChR, a ligand-gated ion channel) |
产品问答
产品问答
参考文献
| 1. Briggs CA, Gr?nlien JH, Curzon P, Timmermann DB, Ween H, Thorin-Hagene K, Kerr P, Anderson DJ, Malysz J, Dyhring T et al.. (2009) Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.. Br J Pharmacol, 158 (6): (1486-94). [PMID:19845675] |
| 2. Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI. (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.. Neuropharmacology, 91 (13): (34-42). [PMID:25497451] |
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