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nortriptyline
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基本描述
| 英文名称 | nortriptyline |
|---|---|
| 别名 | Aventyl,nortriptyline hydrochloride;Pamelor |
| 英文别名 | Aventyl,nortriptyline hydrochloride;Pamelor |
名称和标识符
| EC号 | 200-788-8 |
|---|---|
| IUPAC Name | N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine |
| INCHI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
| InChi Key | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
| Canonical SMILES | CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
| 关联CAS | 72-69-5 |
| PubChem CID | 4543 |
| NSC Number | 757234 |
| MeSH Entry Terms | Allegron;Apo Nortriptyline;Apo-Nortriptyline;Aventyl;Desitriptyline;Desmethylamitriptylin;Gen Nortriptyline;Gen-Nortriptyline;Hydrochloride, Nortriptyline;Norfenazin;Nortrilen;Nortriptyline;Nortriptyline Hydrochloride;Novo Nortriptyline;Novo-Nortriptyline |
数据库链接
| PubChem CID | 4543 |
|---|---|
| DrugBank Ligand | DB00540 |
| CAS Registry No. | 72-69-5 |
| ChEBI | CHEBI:7640 |
| Wikipedia | Nortriptyline |
| ChEMBL Ligand | CHEMBL445 |
| BindingDB Ligand | 50020710 |
| RCSB PDB Ligand | 21B |
| PEP | nortriptyline |
| DrugCentral Ligand | 1971 |
关联配体
| Ligand ID | 2404 |
|---|---|
| 名称 | nortriptyline |
| 别名 | Aventyl® |
| 类别 | Synthetic organic |
| 学名 | methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]propyl})amine |
| 生物活性评价 | Nortryptiline is one of a number of drugs that are cationic amphiphilic in nature, for which anti-SARS-CoV-2 activity has been identified in drug repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693 target="_blank") suggest that this antiviral activity is most likely a result of the drug promoting phospholipidosis via disruption of lipid homeostasis. |
| 评价 | Nortriptyline is a second-generation tricyclic antidepressant (TCA). |
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