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netarsudil

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货号 (SKU) 包装规格 是否现货 价格 数量
N612224-5mg
 5mg 期货 Stock Image
N612224-25mg
 25mg 期货 Stock Image
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Rho associated coiled-coil containing protein kinase 1 Inhibitor Rho associated coiled-coil containing protein kinase 2 Inhibitor
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基本描述

英文名称 netarsudil
别名 AR-11324;AR11324;ester 60;Rhokiinsa,Rhopressa
英文别名 AR-11324;AR11324;ester 60;Rhokiinsa,Rhopressa

名称和标识符

EC号 817-239-9
IUPAC Name [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate
INCHI InChI=1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1
InChi Key OURRXQUGYQRVML-AREMUKBSSA-N
Canonical SMILES CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C
关联CAS 1254032-66-0
PubChem CID 66599893
MeSH Entry Terms AR-13324;netarsudil

关联配体

Ligand ID 9322
名称 netarsudil
别名 Rhopressa®
类别 Synthetic organic
学名 [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate
生物活性评价 At 10 μM, AR-13324 inhibits NET by 96% and SERT by 94% . In a kinase screening panel 0.5 μM AR-13324 inhibited 11 kinases by >90%. Of these 11, ROCK1, ROCK2, PKCδ and PKCη are the only four identified as potential targets for lowering intra-ocular pressure. The S-enantiomer is the more active isomer, with the R-enantiomer having a lower Ki of 106nM and the racemate having a Ki of 4.2nM vs. ROCK2 . Preclinical evaluation is reported in .
评价 Netarsudil (AR-11324) is a combination Rho-associated protein kinase (Rho or ROCK) and norepinephrine transporter (NET) inhibitor . Netarsudil is the S-enantiomeric, 2,4-dimethyl benzoate ester of compound 29 (Ki 0.2nM) described in . Esterification improves bioavailability and corneal penetrating ability of the compound. It is an ocular hypotensive medication.

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参考文献

1. Sturdivant JM, Royalty SM, Lin CW, Moore LA, Yingling JD, Laethem CL, Sherman B, Heintzelman GR, Kopczynski CC, deLong MA.  (2016)  Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma..  Bioorg Med Chem Lett,  26  (10):  (2475-80).  [PMID:27072905]
2. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H.  (2016)  Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms..  Invest Ophthalmol Vis Sci,  57  (14):  (6197-6209).  [PMID:27842161]
3. Lin CW, Sherman B, Moore LA, Laethem CL, Lu DW, Pattabiraman PP, Rao PV, deLong MA, Kopczynski CC.  (2018)  Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma..  J Ocul Pharmacol Ther,  34  (1-2):  (40-51).  [PMID:28609185]
4. Serle JB, Katz LJ, McLaurin E, Heah T, Ramirez-Davis N, Usner DW, Novack GD, Kopczynski CC, ROCKET-1 and ROCKET-2 Study Groups.  (2018)  Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase?Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2)..  Am J Ophthalmol,  186  (13):  (116-127).  [PMID:29199013]
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