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基本描述
| 英文名称 | 1-(2-Naphthoyl)-N-(3-chlorophenyl)piperidine-4-carboxamide |
|---|---|
| 别名 | compound 36 |
| 英文别名 | compound 36 |
名称和标识符
| IUPAC Name | 1-(2-Naphthoyl)-N-(3-chlorophenyl)piperidine-4-carboxamide |
|---|---|
| INCHI | InChI=1S/C23H21ClN2O2/c24-20-6-3-7-21(15-20)25-22(27)17-10-12-26(13-11-17)23(28)19-9-8-16-4-1-2-5-18(16)14-19/h1-9,14-15,17H,10-13H2,(H,25,27) |
| InChi Key | PBXCPFNNNZUANE-UHFFFAOYSA-N |
| Canonical SMILES | Clc1cccc(c1)NC(=O)C1CCN(CC1)C(=O)c1ccc2c(c1)cccc2 |
| PubChem CID | 154699440 |
数据库链接
| PubChem CID | 154699440 |
|---|
关联配体
| Ligand ID | 11083 |
|---|---|
| 名称 | compound 36 [PMID: 32429662] |
| 类别 | Synthetic organic |
| 学名 | 1-(2-Naphthoyl)-N-(3-chlorophenyl)piperidine-4-carboxamide |
| 生物活性评价 |
Inhibitor 36 is selective for MAGL over CB1 and CB2 receptors, and FAAH. It can cross the blood-brain-barrier, and ameliorates depressive-like behaviours induced by |
| 评价 |
Compound 36 is reported as a first-in-class reversible inhibitor of monoacylglycerol lipase (MAGL) |
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参考文献
| 1. Zhi Z, Zhang W, Yao J, Shang Y, Hao Q, Liu Z, Ren Y, Li J, Zhang G, Wang J. (2020) Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.. J Med Chem, 63 (11): (5783-5796). [PMID:32429662] |
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