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Necrostatin-1,特异性坏死病抑制剂

有力的特异性坏死病抑制剂
规格或纯度: ≥99%
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N125522-10mg
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N125522-100mg
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N125522-250mg
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indoleamine 2，3-dioxygenase 1 Inhibitor receptor interacting serine/threonine kinase 1 Inhibitor
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基本描述

规格或纯度 ≥99%
英文名称 Necrostatin-1
别名 5-(1H-吲哚-3-基甲基)-3-甲基-2-硫代-4-咪唑啉酮, 5-(吲哚-3-基甲基)-3-甲基-2-硫代乙内酰脲, MTH-DL-色氨酸|5-[(1H-吲哚-3-基)甲基]-3-甲基-2-硫代咪唑啉-4-酮
英文别名 Necrostatin-1|4311-88-0|MTH-DL-Tryptophan|Necrostatin 1|Nec-1|5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone|5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one|MTH-trp|methyl-thiohydantoin-tryptophan|5-(1H-indol-3-ylmethyl)-3-methy
生化机理 Necrostatin-1是坏死性凋亡的抑制剂（非凋亡性细胞死亡途径）。有力的特异性坏死性肾病抑制剂（EC 50 = 490 nM）。死亡域受体相关衔接子激酶RIP1的选择性变构抑制剂体外（EC 50 = 182 nM）。半胱天冬酶独立的程序性坏死途径。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.

名称和标识符

IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
INCHI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Canonical SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
WGK Germany 3
关联CAS 4311-88-0
PubChem CID 2828334
MeSH Entry Terms Nec-1 compound;necrostatin-1
分子量 259.33

化学和物理性质

溶解性 Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml).
敏感性 对光线敏感；对空气敏感； 对热敏感
熔点 160.0 - 164.0 °C

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

关联配体

Ligand ID 9750
名称 necrostatin-1
别名 nec-1
类别 Synthetic organic
学名 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Necrostatin-1 is an inhibitor of necroptosis . It inhibits RIPK1 and IDO enzyme activities .

相关技术文章

FAQ
PANoptosis: 一种促炎性程序性细胞死亡途径
分类: 技术文章
标签:
PAN凋亡

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参考文献

1. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G et al..  (2008)  Identification of RIP1 kinase as a specific cellular target of necrostatins..  Nat Chem Biol,  4  (5):  (313-21).  [PMID:18408713]
2. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J.  (2005)  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury..  Nat Chem Biol,  1  (2):  (112-9).  [PMID:16408008]
3. Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C et al..  (2012)  Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models..  Cell Death Dis,  3  (13):  (e437).  [PMID:23190609]
4. Alegre-Cortés E et al..  (2020)  Toxicity of Necrostatin-1 in Parkinson's Disease Models..  Antioxidants (Basel),  9  (6):  ().  [PMID:32549347]
5. Li CJ et al..  (2015)  \nSynergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.\n.  Sci Rep,  5  ():  (9819).  [PMID:25909282]
6. Molnár T et al..  (2021)  Caspase-9 acts as a regulator of necroptotic cell death..  FEBS J,  288  (22):  (6476-6491).  [PMID:33899329]
7. Tsui KH et al..  (2017)  DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells..  Reproduction,  154  (2):  (101-110).  [PMID:28624766]
8. Lau H et al..  (2020)  Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets..  PLoS One,  15  (12):  (e0243506).  [PMID:33284818]
9. Matsuda H et al..  (2017)  HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma..  Oncotarget,  8  (41):  (69559-69576).  [PMID:29050225]
10. Bockerstett KA et al..  (2018)  Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis..  Cell Mol Gastroenterol Hepatol,  5  (4):  (678-690.e1).  [PMID:29930985]
11. Dallenga T et al..  (2017)  M.\xa0tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages..  Cell Host Microbe,  22  (4):  (519-530.e3).  [PMID:29024644]
12. Yan S et al..  (2021)  Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells..  Am J Cancer Res,  11  (5):  (2062-2080).  [PMID:34094669]
13. Yan B et al..  (2018)  Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs..  PLoS One,  13  (11):  (e0207760).  [PMID:30462730]
14. Lau H et al..  (2019)  Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function..  Xenotransplantation,    ():  (e12555).  [PMID:31532037]
15. Lau H et al..  (2021)  Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets..  Int J Mol Sci,  22  (16):  ().  [PMID:34445075]
16. Lau H et al..  (2021)  The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture..  Xenotransplantation,  28  (3):  (e12667).  [PMID:33438288]
17. Trimova G et al..  (2020)  Tumour necrosis factor alpha promotes secretion of 14-3-3? by inducing necroptosis in macrophages..  Arthritis Res Ther,  22  ():  (24).  [PMID:32051018]
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