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氯硝柳胺

规格或纯度: 分析标准品

CAS编号: 50-65-7
分子式: C₁₃H₈Cl₂N₂O₄
分子量: 327.12
Beilstein号: 2820605
EC号: 200-056-8,215-811-7
MDL号: MFCD00057597
PubChem编号: 4477

有货

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
N114456-100mg	100mg	现货

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KNa1.1 Activator

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基本描述

规格或纯度	分析标准品
英文名称	Niclosamide
别名	百螺杀
英文别名	2′,5-Dichloro-4′-nitrosalicylanilide
应用	氯硝柳胺是一种驱虫药。对感染人类的绦虫非常有效。氯硝柳胺常用来研究Wnt/Frizzled-1信号传导通路。它查查用于在AML细胞中抑制转录和DNA结合到NF-κB和转录，以及ito诱导凋亡
运输条件	常规运输
产品介绍	水溶解度为5-8ppm，溶于热乙醇、环已酮、氢氧化钠液。氯硝柳胺是一种驱虫药。对感染人类的绦虫非常有效。氯硝柳胺常用来研究Wnt/Frizzled-1信号传导通路。它查查用于在AML细胞中抑制转录和DNA结合到NF-κB和转录，以及ito诱导凋亡 Niclosamide is anthelmintic medicine. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis

名称和标识符

EC号	200-056-8, 215-811-7
IUPAC Name	5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
INCHI	InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChi Key	RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
分子式	C₁₃H₈Cl₂N₂O₄
关联CAS	50-65-7,1420-04-8,1420-04-8 (2-aminoethanol (1:1))
NSC Number	178296
UN Number	3077
UNII	8KK8CQ2K8G
PubChem CID	4477
Beilstein号	2820605
分子量	327.12

化学和物理性质

密度	1.161
熔点	225-230°C

安全信息

象形图	Environmental Hazard Harmful
信号词	Warning
危险声明	H319: Causes serious eye irritation H400: Very toxic to aquatic life H410: Very toxic to aquatic life with long lasting effects
预防措施声明	P305+P351+P338,P273,P280,P501,P391,P264+P265,P337+P317
WGK Germany	2
RTECS	VN8400000
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

靶标

Target ID

385

名称

K_Na1.1

缩写名

SHP2

家族

Calcium- and sodium-activated potassium channels (K_Ca, K_Na)

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	1230	9q34.3	KCNT1	potassium sodium-activated channel subfamily T member 1
Rat	6	1237	3p13	Kcnt1	potassium sodium-activated channel subfamily T member 1
Mouse	6	1224	2 A3	Kcnt1	potassium channel, subfamily T, member 1

OMIM

608167 (Hs)

Entrez Gene

60444 (Rn) , 227632 (Mm) , 57582 (Hs)

UniProtKB

Q6ZPR4 (Mm) , Q5JUK3 (Hs) , Q9Z258 (Rn)

RefSeq Protein

NP_065873 (Hs) , NP_068625 (Rn) , NP_780671 (Mm)

RefSeq Nucleotide

NM_020822 (Hs) , NM_021853 (Rn) , NM_175462 (Mm)

Ensembl Gene

ENSG00000107147 (Hs) , ENSMUSG00000058740 (Mm) , ENSRNOG00000017283 (Rn)

Protein GI

11177892 (Rn) , 224028216 (Mm) , 240255505 (Hs)

Orphanet

317382 (Hs)

ChEMBL Target

CHEMBL4739688 (Hs) , CHEMBL4739708 (Rn) , CHEMBL4739694 (Mm)

关联配体

Ligand ID	8494
名称	niclosamide
别名	VU0243604
类别	Synthetic organic
学名	5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Niclosamide is an oral anthelmintic drug but may have the potential to be used in broader clinical applications. Evidence from repurposing studies suggests some activity against methicillin-resistant Staphylococcus aureus (MRSA), and Zika virus (in vitro) . It is a STAT3 inhibitor, inhibits mTORC1 signaling; positive allosteric modulator (PAM) of the neuropeptide Y₄ receptor .

参考文献

1. Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J. (2016) Discovery of Small-Molecule Modulators of the Human Y4 Receptor.. PLoS ONE, 11 (6): (e0157146). [PMID:27294784]
2. Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C et al.. (2016) Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.. Nat Med, 22 (10): (1101-1107). [PMID:27571349]