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基本描述
| 英文名称 | Il-94 |
|---|
名称和标识符
| IUPAC Name | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(6-fluoro-1H-indazol-4-yl)methyl]-2-N-(2-methoxyethyl)pyrimidine-2,4-diamine |
|---|---|
| INCHI | InChI=1S/C21H23FN8O/c1-31-7-6-30(12-14-8-15(22)9-18-16(14)11-24-27-18)21-23-5-4-19(26-21)25-20-10-17(28-29-20)13-2-3-13/h4-5,8-11,13H,2-3,6-7,12H2,1H3,(H,24,27)(H2,23,25,26,28,29) |
| InChi Key | FTGUWURNNBVUBC-UHFFFAOYSA-N |
| Canonical SMILES | COCCN(c1nccc(n1)Nc1n[nH]c(c1)C1CC1)Cc1cc(F)cc2c1cn[nH]2 |
| PubChem CID | 73348907 |
数据库链接
| ChEMBL Ligand | CHEMBL2386715 |
|---|---|
| PubChem CID | 73348907 |
关联配体
| Ligand ID | 8132 |
|---|---|
| 名称 | Il-94 |
| 类别 | Synthetic organic |
| 学名 | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(6-fluoro-1H-indazol-4-yl)methyl]-2-N-(2-methoxyethyl)pyrimidine-2,4-diamine |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Il-94 is a PAK1 (p21 protein (Cdc42/Rac)-activated kinase 1) inhibitor |
产品问答
产品问答
参考文献
| 1. Abdel-Magid AF. (2013) PAK1: A Therapeutic Target for Cancer Treatment.. ACS Med Chem Lett, 4 (5): (431-2). [PMID:24900689] |
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