91高清自产国产拍,无码免费A级毛片大全,日本欧美国产中文字幕,99re热视频这里只有精品视频首页

400-620-6333

提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.

语言

切换导航

我的购物车

搜索

语言

CAY10603

HDAC6的抑制剂

规格或纯度: 98%

CAS编号: 1045792-66-2
分子式: C₂₂H₃₀N₄O₆
分子量: 446.5
PubChem编号: 24951314

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
H331683-1mg	1mg	现货
H331683-5mg	5mg	现货
H331683-10mg	10mg	现货
H331683-25mg	25mg	现货
H331683-100mg	100mg	现货

查看相关系列

histone deacetylase 1 Inhibitor histone deacetylase 10 Inhibitor histone deacetylase 2 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 8 Inhibitor

Skip to the end of the images gallery

main product photo

Skip to the beginning of the images gallery

基本描述

规格或纯度	98%
英文名称	CAY10603
别名	N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester；HDAC6 inhibitor；tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate；BML-281
英文别名	N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester；HDAC6 inhibitor；tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate；BML-281
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	与HDAC1（IC \| 50 \| = 271 nM），HDAC2（IC \| 50 \| = 252 nM），HDAC3（IC \| 50 \|）相比，HDAC6抑制剂是HDAC6（IC \| 50 \| = 0.002 nM）的选择性有效抑制剂。 = 0.42 nM），HDAC8（IC \| 50 \| = 6851 nM）和HDAC10（IC \| 50 \| = 90.7 nM）。HDAC6抑制剂还阻止了几种胰腺癌细胞系的生长（IC \| 50 \| = 0.1-1μM ）。HDAC6抑制剂在抑制细胞生长方面比广谱HDAC HDAC6 Inhibitor is a selective and potent inhibitor of HDAC6 (IC\|50\|= 0.002 nM, as compared with HDAC1 (IC\|50\|= 271 nM), HDAC2 (IC\|50\|= 252 nM), HDAC3 (IC\|50\|= 0.42 nM), HDAC8 (IC\|50\|= 6851 nM), and HDAC10 (IC\|50\|= 90.7 nM). HDAC6 Inhibitor also prevents the growth of several pancreatic cancer cell lines (IC\|50\|= 0.1-1 μM). HDAC6 Inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroamic acid .

产品属性

pKa值	pKa: 8.12, pKa: 2.41
IC50	HDAC 6: IC??= 0.002 nM; HDAC 1: IC??= 271 nM; HDAC 2: IC??= 252 nM; HDAC 3: IC??= 0.42 nM; HDAC 8: IC??= 6851 nM; HDAC 10: IC??= 90.7 nM; growth of several pancreatIC??ancer cell lines: IC??= 0.1-1 μM

名称和标识符

IUPAC Name	tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
INCHI	InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
InChi Key	WWGBHDIHIVGYLZ-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO
PubChem CID	24951314
分子量	446.5

数据库链接

PubChem CID	24951314
ChEMBL Ligand	CHEMBL511749
BindingDB Ligand	50261816
CAS Registry No.	1045792-66-2

化学和物理性质

溶解性	Soluble in DMSO (~15 mg/ml), and DMF (~15 mg/ml).
密度	~1.2 g/cm3(Predicted)
折光率	n20D1.56 (Predicted)

关联配体

Ligand ID	9664
名称	BML-281
别名	compound 3 [PMID: 18642892]
类别	Synthetic organic
学名	tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
生物活性评价	BML-821 exhibits potent antiproliferative activity against pancreatic cancer cell lines in vitro .
评价	BML-281 is an experimental selective HDAC6/3 inhibitor , that has demonstrated anti-inflammatory activity in a murine model of colonic inflammation .

相关文档

质检报告COA

请输入批号:

SDS中文版 SDS英文版

质量技术规格说明书

附件产品

产品问答

产品问答

登录提交问题

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Kozikowski AP, Tapadar S, Luchini DN, Kim KH, Billadeau DD. (2008) Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.. J Med Chem, 51 (15): (4370-3). [PMID:18642892]
2. Do A, Reid RC, Lohman RJ, Sweet MJ, Fairlie DP, Iyer A. (2017) An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.. J Pharmacol Exp Ther, 360 (1): (140-151). [PMID:27827303]

上海阿拉丁生化科技股份有限公司

销售条款及条件 ? ? ? ? 隐私政策

? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

沪公网安备 31012002004058号沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

危险品化学品经营许可证（带存储）

营业执照(三证合一)